Search for dissertations about: "viral fitness"

Showing result 1 - 5 of 10 swedish dissertations containing the words viral fitness.

  2. 1. Evaluation of reverse transcriptase assay for viral load monitoring

    Author : Gary E Corrigan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Retaining an active reverse transcriptase (RT) enzyme is a fundamental requirement for all retroviruses to replicate. Bearing in mind that HIV has a very high propensity to mutate measuring RT activity to determine the level of retroviral replication has the capacity to eliminate problems associated with divergence, as the virus at all costs must retain an active RT enzyme. READ MORE

  4. 2. Co-evolution of the HIV-1 R5 phenotype and the viral envelope glycoproteins

    Author : Johanna Repits; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; envelope; R5; HIV-1; evolution;

    Abstract : To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. READ MORE

  5. 3. Unifying viral evolution and immunological patterns to investigate risk of HIV-1 disease progression

    Author : Melissa M Norström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : After 30 years of research, the exact mechanisms underlying human immunodeficiency virus type 1 (HIV-1) pathogenesis and disease progression remain elusive. In the absence of highly active antiretroviral therapy, most HIV-infected individuals progress to AIDS within 10 years. READ MORE

  6. 4. The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex

    Author : Jonas Söderholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; NS3; HLA-A2; viral fitness; DNA vaccine;

    Abstract : The hepatitis C virus (HCV) is a blood-borne virus responsible for a major part of liver transplants is the US, and 3% of the population world-wide is infected globally. HCV belongs to the Hepacivirus genus of the Flaviviridae family and is transmitted through infectious blood or blood products. READ MORE

  7. 5. Studies on rotavirus replication

    Author : Alexis Fuentes; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; molekylärbiologi; Molecular Biology;

    Abstract : Rotavirus is the leading cause of dehydrating diarrhea in infants and young children globally. In cells infected with rotavirus SA11 the synthesis of viral RNA and protein predominated already after a few hours. Cellular RNA remained intact, but viral mRNA was preferentially utilised for protein synthesis. READ MORE