Search for dissertations about: "viral hepatitis"

Showing result 11 - 15 of 87 swedish dissertations containing the words viral hepatitis.

  2. 11. Genetic variability of hepatitis B virus in chronic infection

    Author : Charles Hannoun; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ; hepatitis B virus; mutation; genotype; phylogeny; Recombination; coinfection; interferon; response;

    Abstract : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. READ MORE

  4. 12. The hepatitis B virus – Insights into genetic variability, evolution and Bayesian phylogeographic inference

    Author : Mikael Ingman; Malmö Klinisk virologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatit B; evolutionsbiologi; fylogeni; Hepatitis B; evolutionary dynamics; Phylogeography;

    Abstract : In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. READ MORE

  5. 13. Opportunistic viral infection after paediatric transplantation

    Author : Carola Kullberg-Lindh; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Paediatric liver transplantation; paediatric stem cell transplantation; immunosuppression; opportunistic; CMV; EBV; AdV; HHV-6; real-time PCR; monitoring; specimen; post transplant lymphoproliferative disease;

    Abstract : Background: Opportunistic viral infections can cause considerable morbidity and mortality in organ and stem cell transplanted (SCT) patients, mainly due to iatrogenic T cell dysfunction. Whereas in SCT patients, in general the immunosuppressive treatment can be discontinued after 6-12 months, for the majority of organ transplanted patients, the need for treatment is life-long. READ MORE

  6. 14. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection

    Author : Åsa Alsiö; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : infectious diseases; virology; hepatitis c; treatment;

    Abstract : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. READ MORE

  7. 15. Improving immunogenicity of hepatitis B and C viral proteins for vaccine design

    Author : Antony Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The hepatitis B and C virus (HBV, HCV) both presents a global health challenge, with an estimated 350 million individuals chronically infected with HBV and over 200 million infected with HCV. Reported cases of HBV and HCV have declined significantly due to screening of blood products and the availability of HBV vaccination. READ MORE