Search for dissertations about: "viral hepatitis"

Showing result 16 - 20 of 87 swedish dissertations containing the words viral hepatitis.

  1. 16. Hepatitis C virus kinetics during antiviral treatment

    Author : Tony Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C virus RNA; genotype; kinetics; interferon-alpha; ribavirin.;

    Abstract : It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear the infection in 40-80% of the patients depending on treatment and HCV genotype. READ MORE

  2. 17. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

    Author : Robert Rönn; Anders Hallberg; Anja Sandström; Federico Corelli; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; hepatitis C virus; HCV; NS3 protease inhibitor; acyl sulfonamide; bioisostere; palladium; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi;

    Abstract : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). READ MORE

  3. 18. Prevention and treatment of hepatitis B virus infection

    Author : Per Sangfelt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis B virus; vaccination; treatment; interferon-alpha; larnivudine; famciclovir;

    Abstract : Despite 25 years of effective vaccines and availability of treatment options for 15 years, hepatitis B virus (HBV) infections continue to be a major global health problem. In Sweden, selective screening and vaccination programmes are used in defined high-risk groups such as newborns of chronic HBV carrier mothers and health care workers with risk of blood exposure. READ MORE

  4. 19. Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus

    Author : Sebastian Malmström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : hepatitis B virus; real-time PCR; lamivudine resistance; genotypes; replication;

    Abstract : Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as lamivudine, entecavir, and tenofovir. READ MORE

  5. 20. Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR

    Author : Kasthuri Prakash; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; NTCP; HBV DNA; HBV RNA; subviral particles; integrations; droplet digital PCR;

    Abstract : Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify HBV infection and monitor treatment efficacy, including HBV DNA, surface antigen (HBsAg) and e antigen (HBeAg) in serum as well as HBV DNA and RNA in liver tissue. READ MORE