Search for dissertations about: "viral hepatitis"

Showing result 6 - 10 of 87 swedish dissertations containing the words viral hepatitis.

  2. 6. Hepatitis B virus replication and integration

    Author : Simon B. Larsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; replication; integration; HBV DNA; HBsAg;

    Abstract : Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no liver disease and express the e antigen (HBeAg). READ MORE

  4. 7. Interaction Characteristics of Viral Protease Targets and Inhibitors : Perspectives for drug discovery and development of model systems

    Author : Cynthia F Shuman; Jordan J N Tang; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; viral proteases; biomolecular interactions; kinetics; thermodynamics; biosensors; drug discovery; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Viral proteases are important targets for anti-viral drugs. Discovery of protease inhibitors as anti-viral drugs is aided by an understanding of the interactions between viral protease and inhibitors. This thesis addresses the characterization of protease-inhibitor interactions for application to drug discovery and model system development. READ MORE

  5. 8. Functional role of T-cell activation in viral hepatitis

    Author : Jessica Nyström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HBV; HCV; HBcAg; NS3 4A; HBsAg; T-cells;

    Abstract : Hepatitis B and C (HBV, HCV) constitute global health problems and there are approximately 350 million chronically HBV infected people around the world, most of them are found in East and South East Asia and Africa. Worldwide there are 170 million HCV infected individuals with the highest prevalence seen in Egypt. READ MORE

  6. 9. Co-morbidity and mortality in Swedish patients with haemophilia - A register study

    Author : Susanna Lövdahl; Malmö Klinisk koagulationsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haemophilia; registry; HIV; viral hepatitis; malignancy; hypertension; cardiovascular disease;

    Abstract : Haemophilia is an X-linked inherited recessive disorder affecting males. The increased risk of hemorrhage is explained by the deficiency in either coagulation factor VIII (haemophilia A) or IX (haemophilia B). The severity of haemophilia A and B is characterized by the bleeding pattern. READ MORE

  7. 10. The impact of viral vaccines in immunosuppressed and at-risk individuals

    Author : Anja Rosdahl; Torbjörn Norén; Helena Hervius Askling; Sara Cajander; Leonardus (Leo) Visser; Örebro universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccine; Vaccine failure; Immunocompromised host; Hepatitis A; Tick borne encephalitis; SARS-CoV-2; Innate immunity; Adaptive immunity;

    Abstract : Vaccines have saved millions of lives, but for some individuals with a defective immune system the protection may be uncertain. This thesis aims to assess the immune response following viral vaccines in immunocompromised patients and in other groups at-risk. READ MORE