Search for dissertations about: "viral incorporation"

Showing result 1 - 5 of 16 swedish dissertations containing the words viral incorporation.

  2. 1. Influenza Neuraminidase : Novel mechanisms of influenza NA that enable adaptation and promote diversification

    Author : Hao Wang; Robert Daniels; Colin Russell; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza; IAV; neuraminidase; transmembrane domain; the central Ca2 binding site; heterotetrameric formation; viral incorporation; evolution; adaptation; diversification; Biochemistry; biokemi;

    Abstract : Influenza A viruses (IAVs) are one of the most common human respiratory pathogens and are largely responsible for the seasonal influenza epidemics that cause mild to severe disease. The two IAV glycoproteins, hemagglutinin (HA or H) and neuraminidase (NA or N), serve as the major surface antigens and also are the main determinants of infectivity, pathogenicity and transmissibility. READ MORE

  4. 2. Incorporation of cellular proteins into enveloped virus particles

    Author : Maria Hammarstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MLV; HIV-1; assembly; protein sorting; HfIV-6A; autoimmunity; MS;

    Abstract : This thesis work aimed to investigate the assembly and budding of enveloped virus particles with focus on the fate of cellular proteins, present in or near the plasma membrane (PM) where the budding occurs. It was previously shown that compact viruses, like alphaviruses, with a covering outer protein coat, did not contain any cellular proteins in the envelope. READ MORE

  5. 3. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

    Author : Petra Henning; Göteborgs universitet; []
    Keywords : Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

    Abstract : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. READ MORE

  6. 4. Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity

    Author : Alenka Jejcic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1;

    Abstract : HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. READ MORE

  7. 5. Pseudovirions in the Study of Papilloma- and Polyomaviruses

    Author : Helena Faust; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human papilloma- and polyomaviruses; pseudovirions; serology;

    Abstract : The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. READ MORE