Search for dissertations about: "viral integrations"

Found 3 swedish dissertations containing the words viral integrations.

  2. 1. Comprehensive analysis of structural genomic alterations in cancer : Computational approaches for identifying cancer driver events

    Author : Babak Alaei-Mahabadi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic structural variations; viral integrations; gene fusions; somatic genomic alterations;

    Abstract : The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and size, comprising single nucleotide variants (SNVs), small insertions or deletions (indels), structural variations (SVs) or foreign DNA insertions such as viral DNA. READ MORE

  4. 2. Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR

    Author : Kasthuri Prakash; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; NTCP; HBV DNA; HBV RNA; subviral particles; integrations; droplet digital PCR;

    Abstract : Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify HBV infection and monitor treatment efficacy, including HBV DNA, surface antigen (HBsAg) and e antigen (HBeAg) in serum as well as HBV DNA and RNA in liver tissue. READ MORE

  5. 3. Genomic and transcriptomic profiles in chronic hepatitis B infection

    Author : Johan Ringlander; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; hepatitis delta virus; integration; deep sequencing; cirrhosis; HCC;

    Abstract : Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are attributed to HBV infection. The virus is adapted to the human host and has developed mechanisms to evade immunity. READ MORE