Advanced search

Showing result 1 - 5 of 16 swedish dissertations matching the above criteria.

  2. 1. Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

    Author : Angelica Ehrenberg; Helena Danielson; Celia Schiffer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; drug discovery; viral proteases; inhibitors; Hepatitis C; NS3; cytomegalovirus; Biokemi; Biochemistry;

    Abstract : Viral proteases are often considered to be attractive drug targets because of their crucial function in the viral replication machinery. In order to increase our knowledge of these important targets and to contribute to the discovery and development of new antiviral drugs, the proteases from hepatitis C virus (HCV) and human cytomegalovirus (HCMV) have been produced and their interactions with inhibitors and fragments have been characterized, using enzyme inhibition and SPR biosensor based interaction assay. READ MORE

  4. 2. Interaction Characteristics of Viral Protease Targets and Inhibitors : Perspectives for drug discovery and development of model systems

    Author : Cynthia F Shuman; Jordan J N Tang; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; viral proteases; biomolecular interactions; kinetics; thermodynamics; biosensors; drug discovery; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Viral proteases are important targets for anti-viral drugs. Discovery of protease inhibitors as anti-viral drugs is aided by an understanding of the interactions between viral protease and inhibitors. This thesis addresses the characterization of protease-inhibitor interactions for application to drug discovery and model system development. READ MORE

  5. 3. New aspects of allergic mechanisms and innate immunity in asthma. Alarmins as upstream mediators of asthma inflammation

    Author : Sangeetha Ramu; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Aeroallergens; Airway inflammation; Bronchial epithelial cells; Bronchial smooth muscle cells; Metabolic DAMPs; Proteases; Allergen immunotherapy; Mast cells; Viral infections; innate immunity;

    Abstract : Asthma is a chronic inflammatory lung disease affecting over 300 million individuals worldwide. Both respiratory viral infections and aeroallergens have been identified as important risk factors for asthma. READ MORE

  6. 4. Modeling the Interaction Space of Biological Macromolecules: A Proteochemometric Approach : Applications for Drug Discovery and Development

    Author : Aleksejs Kontijevskis; Jarl Wikberg; Jan Komorowski; Robert Glen; Uppsala universitet; []
    Keywords : Bioinformatics; proteochemometrics; bioinformatics; chemoinformatics; chemical space; QSAR; retroviral proteases; HIV-1; drug resistance; pharmacogenomics; cytochrome P450; GPCRs; melanocortin receptors; interactome; machine-learning; rough sets; Bioinformatik;

    Abstract : Molecular interactions lie at the heart of myriad biological processes. Knowledge of molecular recognition processes and the ability to model and predict interactions of any biological molecule to any chemical compound are the key for better understanding of cell functions and discovery of more efficacious medicines. READ MORE

  7. 5. Modulation of the deubiquitnating system during lymphoid cell activation and viral infection

    Author : Ulrika Rolén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The family of ubiquitin-specific proteases (USPs) removes ubiquitin from its conjugates and regulates the production and recycling of ubiquitin. USPs are thereby critically involved in the control of important functions such as cell growth, differentiation and apoptosis. Increasing evidence implicates USPs deregulation in malignant transformation. READ MORE