Search for dissertations about: "viral vector"

Showing result 1 - 5 of 79 swedish dissertations containing the words viral vector.

  2. 1. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

    Author : Petra Henning; Göteborgs universitet; []
    Keywords : Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

    Abstract : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. READ MORE

  4. 2. Replication-competent adenovirus 11p vector as a new oncolytic agent

    Author : Jim Silver; Ya-Fang Mei; Gunnel Halldén; Umeå universitet; []
    Keywords : Virologi; Adenovirus; Vector; mikrobiologi; Microbiology;

    Abstract : Human adenoviruses (Ads) as vectors have been studied for cancer gene therapy for several decades due to their ability to shut down host cell replication and lyse tumour cells. Ad5 of species C is commonly used as a replication-defective or a replication-competent vector. READ MORE

  5. 3. Towards Mosquitocides for Prevention of Vector-Borne Infectious Diseases : discovery and Development of Acetylcholinesterase 1 Inhibitors

    Author : Sofie Knutsson; Anna Linusson; Fredrik Almqvist; Andreas Larsson; Ulf Nilsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mosquito; vector-borne diseases; vector control; insecticide; acetylcholinesterase; medicinal chemistry; high-throughput screening; organic synthesis; homology modeling; structure activity relationship; structure selectivity relationship; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Abstract : Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public health, with young children being among the worst affected. These diseases are transmitted by mosquitoes, also called disease vectors, which are able to transmit both parasitic and viral infections. READ MORE

  6. 4. Adenovirus vector systems permitting regulated protein expression and their use for in vivo splicing studies

    Author : Magnus Molin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus; vector; inducible; gene expression; ASF SF2; splicing; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : We have constructed two adenovirus-based gene expression vector systems permitting regulated protein expression. They are based on the tetracycline-regulated Tet-ON- and the progesterone antagonist RU 486-regulated gene expression systems, which were rescued into E1-deficient adenovirus vectors. READ MORE

  7. 5. Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines

    Author : Anne-Marie T Ciupitu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : heat shock protein 70; vaccination; tumour antigens; in vivo protection; T cell activation; adjuvant; LCMV;

    Abstract : New efficient vaccines against cancers and infectious diseases are in demand. In 1993 heat shock protein 70 (hsp70) purified from tumour was shown to elicit tumour protection in mice. It was also shown that the protection was not mediated by the hsp70 itself, but by tumour-specific peptides bound to the molecule. READ MORE