Search for dissertations about: "viral vectors"

Showing result 1 - 5 of 74 swedish dissertations containing the words viral vectors.

2. 1. Viral vectors, in innate and adaptive immunity

   Author : Tanja I Näslund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Recombinant viral vectors and DNA vectors induce strong immune responses in animal models. However, in clinical trials, the generation of immune responses is less robust, suggesting that further optimization and a deeper understanding of nucleic acid-based vaccines are required. READ MORE

4. 2. Construction of Adenovirus Vectors for Studies of Protein Function and RNA Interference

   Author : Saideh Berenjian; Göran Akusjärvi; Mikael Berg; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Adenovirus; viral vectors; VA RNAI II; RNAi; Tet-ON OFF; RNA splicing; Mikrobiologi; Microbiology; Mikrobiologi;

   Abstract : During an adenovirus infection the accumulation of alternatively spliced mRNAs is subjected to a tight temporal regulation. The IIIa protein is a structural protein expressed exclusively late after infection. READ MORE

5. 3. Enhancing the efficiency of viral and non-viral gene delivery vectors

   Author : Safa Bazaz; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Gene therapy, which involves the introduction, alteration, or deletion of genetic material within cells to treat or prevent disease, holds great promise for addressing various genetic disorders and other medical conditions. However, several challenges remain in the field, particularly concerning nucleic acid delivery into target cells. READ MORE

6. 4. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

   Author : Petra Henning; Göteborgs universitet; []
   Keywords : Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

   Abstract : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. READ MORE

7. 5. Alphavirus vectors as recombinant vaccines

   Author : Peter Berglund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Semliki Forest virus; Alphavirus; Synthetic vaccmes; Influenza A virus; HIV-I; SIV; DNA vaccines; AIDS vaccines; Influenza vaccine;

   Abstract : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. READ MORE