Search for dissertations about: "viral vectors"

Showing result 1 - 5 of 68 swedish dissertations containing the words viral vectors.

  1. 1. Viral vectors, in innate and adaptive immunity

    University dissertation from Stockholm : Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology

    Author : Tanja I Näslund; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Recombinant viral vectors and DNA vectors induce strong immune responses in animal models. However, in clinical trials, the generation of immune responses is less robust, suggesting that further optimization and a deeper understanding of nucleic acid-based vaccines are required. READ MORE

  2. 2. Construction of Adenovirus Vectors for Studies of Protein Function and RNA Interference

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Saideh Berenjian; Uppsala universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Adenovirus; viral vectors; VA RNAI II; RNAi; Tet-ON OFF; RNA splicing; Mikrobiologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi;

    Abstract : During an adenovirus infection the accumulation of alternatively spliced mRNAs is subjected to a tight temporal regulation. The IIIa protein is a structural protein expressed exclusively late after infection. READ MORE

  3. 3. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Petra Henning; Göteborgs universitet.; Gothenburg University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

    Abstract : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. READ MORE

  4. 4. Alphavirus vectors as recombinant vaccines

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Peter Berglund; Karolinska Institutet.; Karolinska Institutet.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Semliki Forest virus; Alphavirus; Synthetic vaccmes; Influenza A virus; HIV-I; SIV; DNA vaccines; AIDS vaccines; Influenza vaccine;

    Abstract : ALPHAVIRUS VECTORS AS RECOMBINANT VACCINES Peter Berglund Doctoral dissertation from the Microbiology and TumorbiologyCenter Karolinska Institute, Sweden This thesis describes further developments of an expression system based on thealphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structuralproteins, and a 5' ORF coding for the viral replicase. READ MORE

  5. 5. Generation of induced neurons via direct conversion in vivo and in vitro

    University dissertation from Neurobiology

    Author : Olof Torper; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular reprogramming; cell replacement therapies; induced dopaminergic neurons; in vivo reprogramming; Lentiviral vectors; AAV vectors;

    Abstract : Popular Abstract in Swedish I min avhandling har jag tittat på möjligheten att göra om mänskliga hudceller direkt till dopaminerga nervceller. Dessa uppvisar flera egenskaper tillskrivna de dopaminerga nervceller vi hittar i hjärnan. READ MORE