Search for dissertations about: "viral vectors"
Showing result 11 - 15 of 74 swedish dissertations containing the words viral vectors.
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11. Cancer therapy using viral and bacterial proteins as vectors for vaccines or as carriers of cytostatics
Abstract : New cancer therapies are urgently needed, since available treatment options today have negative side effects, and cure only about half of the patients with invasive cancer. One, relatively new, option is to vaccinate against cancer, by introducing an antigen that is present on the tumor cells into the patient to stimulate specific immunity against the tumor. READ MORE
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12. Precision mapping of gene expression and proteins in the brain using gene editing and barcoded viral vectors
Abstract : The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. READ MORE
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13. Development of Adenoviral Vectors for Studying Hematopoietic Stem Cell Function
Abstract : Hematopoietic stem cells (HSCs) are defined by their capacity to self-renew and differentiate into all hematopoietic cell lineages. Postnatally, HSCs reside predominantly in the bone marrow and are relatively rare, but important cells because of their therapeutic potential in bone marrow transplantation protocols and in their involvement in the origin of certain leukemias. READ MORE
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14. Cell-penetrating peptides as delivery vectors for oligonucleotides and proteins : Studies on applications and toxicity
Abstract : Cell-penetrating peptides (CPPs) have for a little bit more than a decade been employed as delivery vectors for a wide range of cargoes, ranging from gold particles to entire plasmids. Although CPP are well studied and utilized in numerous publications, our knowledge about CPP mediated transport is still poor. READ MORE
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15. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations
Abstract : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. READ MORE