Search for dissertations about: "viral vectors"

Showing result 16 - 20 of 74 swedish dissertations containing the words viral vectors.

  2. 16. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors

    Author : Ayse Ulusoy; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; adeno-associated virus; dopamine; α-synuclein; tyrosine hydroxylase; RNAinterference; shRNA; substantia nigra; animal models; dyskinesia;

    Abstract : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. READ MORE

  4. 17. Imported infections’ importance : global change driving Dengue dynamics

    Author : Mikkel B. Quam; Joacim Rocklöv; Annelies Wilder-Smith; Eduardo Massad; Dave D. Chadee; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dengue; Zika; Vector-borne Disease; Aedes; Global Change; Climate Change; Viral Evolution; Phylogenetics; Travel; Interconnectivity; Disease Modeling; Madeira; Italy; Japan; Europe;

    Abstract : Background Dengue is a significant problem of international health concern. According to the World Health Organization in 2012, globally, dengue is “the most important mosquito borne viral disease” with incidence 30 higher than it had been 50 years ago. READ MORE

  5. 18. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease

    Author : Sofia Hult Lundh; Translationell neuroendokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; depression; anxiety; metabolism; neuroendocrinology; mouse models; BACHD; rAAV vectors; leptin;

    Abstract : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. READ MORE

  6. 19. Strategies of gene and immune therapy for tumors and viral diseases

    Author : Herman José Arteaga; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Intracellular cytokines; DNA vaccine-GM-CSF; HIV- 1; RNA interference;

    Abstract : In the treatment of tumors and viral diseases such as HIV-1 infection, immunotherapeutic strategies do not seem to have enough capacity to eradicate an already established disease. However, these strategies could play a unique role as adjuvant treatments of therapies that eliminate the main tumor or viral load in order to avoid the relapse of the disease. READ MORE

  7. 20. Semliki forest virus-derived packaging system for production of retroviral vectors

    Author : Ke-Jun Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Moloney murine leukemia virus; Semliki Forest virus; gene therapy; retroviral vector; intron; human bone marrow stromal cell;

    Abstract : Gene therapy is a treatment of disease by transfer of genetic material into somatic cells of an individual. Successful gene therapy depends on a delivery system which can efficiently transfer the gene into target cells and lead to high level expression of the gene. READ MORE