Search for dissertations about: "virtual screening"

Showing result 21 - 25 of 37 swedish dissertations containing the words virtual screening.

  2. 21. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents

    Author : Wojciech W. Krajewski; Sherry L. Mowbray; Torsten Unge; Thomas C. Terwilliger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Structural biology; Strukturbiologi;

    Abstract : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. READ MORE

  4. 22. The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation

    Author : Cecilia Granéli; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenchymal stem cells; Mesenchymal stromal cells; Osteogenic differentiation; Adipogenic differentiation; Bone regeneration; Inflammation; Monocytes; Infection; Bacterial membrane vesicles; Compromised bone healing; Cell surface proteins; CD-markers; Osseointegration; Regenerative medicine;

    Abstract : Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective of the present thesis was to study different aspects of the osteogenic potential of MSCs. READ MORE

  5. 23. Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products

    Author : Anders Lindgren; Mikael Elofsson; Nicholas Westwood; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic synthesis; quinazolinone; ARTD; PARP; total synthesis; polyphenols; bensofuranes; organisk kemi; Organic Chemistry;

    Abstract : Diphtheria Toxin-like ADP-RibosyltransferasesThe Human ADP-ribosyl transferases (ARTDs) are a group of poorly studied enzymes which are believed to be involved in e.g. DNA repair, protein degradation, transcription regulation and cell death. Medicinal chemistry programmes aimed at developing selective inhibitors of these ARTDs were initiated. READ MORE

  6. 24. Failure prediction of orthotropic Non-Crimp Fabric reinforced composite materials

    Author : Henrik Molker; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Orthotropic; Non crimp-fabric; Failure initiation; Design methodology; Carbon fibre composite;

    Abstract : The automotive industry needs to reduce the energy consumption to decrease the impact on the environment. One part of this is to reduce the weight of cars, thereby reducing the fuel consumption. A promising way to be successful with this is to introduce carbon fibre composites in the structural parts. READ MORE

  7. 25. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

    Author : Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

    Abstract : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. READ MORE