Search for dissertations about: "virulence"

Showing result 16 - 20 of 462 swedish dissertations containing the word virulence.

  2. 16. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

    Author : Margareta Aili; Roland Rosqvist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. READ MORE

  4. 17. Haemophilus influenzae-induced acute otitis media. Aspects of virulence and protection in an animal model

    Author : Åsa Melhus; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteriology; Microbiology; conjugate vaccine; protection; virulence; acute otitis media; Haemophilus influenzae; animal model; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : Acute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H. READ MORE

  5. 18. The multifunctional GAP protein YopE of Yersinia is involved in effector translocation control and virulence

    Author : Elin Isaksson; Hans Wolf-Watz; Joseph Barbieri; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; YopE; GAP activity; translocation control; virulence; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Gram-negative bacterium Yersinia pseudotuberculosis employs a type 3 secretion system (T3SS) to establish infections. The T3SS translocates a diverse set of effector proteins directly into the host cells. READ MORE

  6. 19. Disarming bacteria : a structure-based approach to design an anti-virulence drug against Listeria monocytogenes

    Author : Melanie Oelker; A. Elisabeth Sauer-Eriksson; Fredrik Almqvist; Karina Persson; Tiziano Tuccinardi; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistances; anti-virulence drug; Listeria monocytogenes; virulence regulation; PrfA; structure-based drug design; ring-fused 2-pyridones; allosteric regulation; Biochemistry; biokemi; medicinal chemistry; läkemedelskemi; molekylär cellbiologi; molecular cell biology; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Abstract : Antibiotic resistances are one of the biggest threats to global health and if we don’t change our behavior and way of using antibiotics we will end up in a ‘post-antibiotic era’, in which common infections and minor injuries can once kill again and up to 10 million deaths per year may occur by 2050. Therefore, there is a high need for new anti-bacterial drugs, especially of alternatives to existing antibiotics with already described resistances. READ MORE

  7. 20. Virulence Factors and Motility Mechanisms of Pathogenic Neisseria

    Author : Jens Eriksson; Ann-Beth Jonsson; Helena Aro; Tone Tønjum; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neisseria; Virulence factors; Type IV pili; PilT; PilU; NafA; NhhA; Twitching motility; molekylärgenetik; Molecular Genetics;

    Abstract : Neisseria gonorrhoeae and Neisseria meningitidis are two closely related human specific pathogens. Neisseria gonorrhoeae is the causative agent for the sexually transmitted disease gonorrhea and often causes asymptomatic infections in women which is a cause of infertility. READ MORE