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Showing result 1 - 5 of 189 swedish dissertations matching the above criteria.

  2. 1. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

    Author : Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. READ MORE

  4. 2. Vitamin D in Depression and Suicidality

    Author : Cécile Grudet; Lund Psykiatri; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vitamin D; depression mood disorders; suicidality; inflammation;

    Abstract : .... READ MORE

  5. 3. Aspects of Vitamin D : Prevalence of deficiency and impact on musculoskeletal parameters

    Author : Anne Björk; Östen Ljunggren; Gunnar Johansson; Andreas Kindmark; Anna Spångeus; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vitamin D; CYP2R1; Vitamin D receptor Gene; Polymorphisms; Muscle Strength; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Vitamin D is central in calcium turnover, and adequate levels are important for skeletal health. It is not clear how large contributions from food and sunlight are in Swedish primary care patients, considering the low radiation of UVB in Sweden and fortification of some foods, and whether differences exist between patients of immigrant and Swedish origin. READ MORE

  6. 4. Vitamin D Hydroxylating Enzymes and Analogues in Parathyroid Tumors and Breast Cancer

    Author : Ulrika Segersten; Gunnar Westin; Per Hellman; Göran Åkerström; Martin Bäckdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; hyperparathyroidism; breast cancer; vitamin D; CYP27B1; CYP24A1; vitamin D analogues; ketoconazole; vitamin D receptor; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : In hyperparathyroidism (HPT) raised serum concentrations of ionized calcium is caused by increased secretion of parathyroid hormone (PTH) by parathyroid tumors. Active vitamin D, 1α,25-dihydroxyvitamin D3, is known to suppress PTH secretion and to reduce proliferation of parathyroid tumor cells. READ MORE

  7. 5. Vitamin D and Vitamin D-binding Protein in Psoriasis and Effects of Treatment

    Author : Maria Siekkeri Vandikas; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; psoriasis; vitamin D; vitamin D-binding protein; phototherapy; tumor necrosis factor α inhibitor;

    Abstract : Background: Topical vitamin D analogues constitute an established treatment for psoriasis but the role of vitamin D in the pathogenesis of the disease remains controversial. The in loco production and immunomodulatory effects of vitamin D need to be elucidated. READ MORE