Search for dissertations about: "voltage gated potassium channel"

Showing result 1 - 5 of 25 swedish dissertations containing the words voltage gated potassium channel.

2. 1. Molecular aspects on voltage-sensor movement

   Author : Amir Broomand; Fredrik Elinder; Guiscard Seebohm; Linköpings universitet; []
   Keywords : Potassium channels; voltage-gated; chemistry; metabolism; physiology; patch-clamp techniques; oocytes; MEDICINE; MEDICIN;

   Abstract : Voltage-gated ion channels are fundamental for electrical signaling in living cells. They are composed of four subunits, each holding six transmembrane helices, S1-S6. Each subunit contains a voltage-sensor domain, S1-S4, and a pore domain, S5-S6. READ MORE

4. 2. Conformational Changes during Potassium-Channel Gating

   Author : Jakob Renhorn; Fredrik Elinder; David Engblom; Stephan Pless; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ion-channel; electrophysiology; neuron; Jonkanal; neurologi; elektrofysiologi; neuron; aktionspotential;

   Abstract : Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. READ MORE

5. 3. Computational Analysis of Molecular Recognition Involving the Ribosome and a Voltage Gated K+ Channel

   Author : Martin Andér; Johan Åqvist; Lennart Nilsson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; computer simulations; molecular dynamics; ligand binding; binding free energy; linear interaction energy; codon recognition; translation termination; release factor; voltage gated potassium ion channel; Kv1.5; Structural biology; Strukturbiologi; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Abstract : Over the last few decades, computer simulation techniques have been established as an essential tool for understanding biochemical processes. This thesis deals mainly with the application of free energy calculations to ribosomal complexes and a cardiac ion channel. READ MORE

6. 4. Polyunsaturated Fatty Acids Modifying Ion Channel Voltage Gating

   Author : Sara Börjesson; Fredrik Elinder; Klaus Benndorf; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Voltage-gated ion channels play fundamental roles in neuronal excitability and therefore dysfunctional channels can cause disease. Epilepsy is such a disease, affecting about 1% of the population and being characterized by synchronous electric activity of large groups of neurons leading to various types of seizures. READ MORE

7. 5. Voltage sensor activation and modulation in ion channels

   Author : Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

   Abstract : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. READ MORE