Search for dissertations about: "voltage-dependent calcium channel"

Showing result 1 - 5 of 10 swedish dissertations containing the words voltage-dependent calcium channel.

  2. 1. Studies of individual pancreatic -cells : Electrophysiological analysis of rhythmic behaviour and development of new techniques

    Author : Staffan Dryselius; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic beta-cells; insulin release; signal transduction; cytoplasmic calcium; oscillations; patch clamp; ATP-regulated potassium channels; voltage-dependent calcium channels; metabolism; calcium ion; strontium ion; manganese ion; wavelets; de-noising; pattern recognition; superfusion; solution changes; microscopic labelling; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The insulin concentration in blood varies periodically, which is believed to prevent down-regulation of the hormone receptors. Loss of the regular insulin oscillations is considered to be an early sign of developing diabetes. READ MORE

  4. 2. Host-parasite interactions in the dissemination of Toxoplasma gondii

    Author : Sachie Kanatani; Antonio Barragan; Per Uhlén; Isabelle Tardieux; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apicomplexa; dendritic cells; microglia; cell migration; 14-3-3 proteins; GABAergic signaling; voltage-dependent calcium channel; host-parasite interaction; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Toxoplasma gondii is an obligate intracellular parasite that infects virtually all warm-blooded organisms. Systemic dissemination of T. gondii in the organism can cause life-threatening infection that manifests as Toxoplasma encephalitis in immune-compromised patients. READ MORE

  5. 3. The interplay of ions in the stimulation of the pancreatic -cell

    Author : Michael Eberhardson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; pancreatic β-cells; cytoplasmic calcium; oscillations; glucose; tetrodotoxin; tolbutamide; veratridine; tetraethylammonium; quinine; cesium; H2DIDS; furosemide; transients; microfluorometry; fura-2; MQAE; calcium channels; potassium channels; sodium channels; chloride channels; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Glucose stimulation of insulin release is mediated by depolarisation of the pancreatic β-cells with accompanying entry of Ca2+ through voltage-dependent channels. An important feature of the glucose-induced depolarisation is its rhythmicity causing oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), which trigger pulsatile release of insulin. READ MORE

  6. 4. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Author : Jenny Vikman; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Abstract : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. READ MORE

  7. 5. Signaling determinants in Trojan horse-mediated dissemination of Toxoplasma gondii

    Author : Einar B. Ólafsson; Antonio Barragan; Eva Frickel; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apicomplexa; leukocyte motility; dendritic cell; amoeboid migration; host-parasite interactions; podosome; integrin; ITGB1; ECM; MAT; TIMP; MMP; MAPK; Erk; RTK; HGFR; Ras; calcium; VDCC; VGCC; calmodulin; CaMkII; CD63; FAK; SRC; Pi3k; hypermigration; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Toxoplasma gondii is an obligate intracellular parasite that infects all warm-blooded vertebrates including one third of the global human population. While infection is typically asymptomatic in healthy human hosts, reactivated and acute infection in immunosuppressed or immunecompromised individuals can lead to lethal toxoplasmic encephalitis After ingestion, the parasite crosses the intestinal epithelium and rapidly achieves systemic dissemination, ultimately establishing chronic infection in the brain. READ MORE