Search for dissertations about: "voltage-sensor"

Showing result 1 - 5 of 19 swedish dissertations containing the word voltage-sensor.

2. 1. Dynamics of the voltage-sensor domain in voltage-gated ion channels : Studies on helical content and hydrophobic barriers within voltage-sensor domains

   Author : Christine S. Schwaiger; Erik Lindahl; Lynn Kamerlin; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage-sensor; VSD; Kv1.2- 2.1; F233; hydrophobic barrier; alpha-helix; 3 10 -helix; Biological physics; Biologisk fysik;

   Abstract : Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. READ MORE

4. 2. Voltage sensor activation and modulation in ion channels

   Author : Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

   Abstract : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. READ MORE

5. 3. Molecular aspects on voltage-sensor movement

   Author : Amir Broomand; Fredrik Elinder; Guiscard Seebohm; Linköpings universitet; []
   Keywords : Potassium channels; voltage-gated; chemistry; metabolism; physiology; patch-clamp techniques; oocytes; MEDICINE; MEDICIN;

   Abstract : Voltage-gated ion channels are fundamental for electrical signaling in living cells. They are composed of four subunits, each holding six transmembrane helices, S1-S6. Each subunit contains a voltage-sensor domain, S1-S4, and a pore domain, S5-S6. READ MORE

6. 4. Voltage-Sensor Domains of Ion Channels : Physiology, Regulation, and Role in Disease

   Author : Michelle Nilsson; Antonios Pantazis; Fredrik Elinder; Henry M. Colecraft; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Brain function depends on the ability of neurons to sense and respond to electricity, which is mediated by small modules in the neuronal membrane called voltage-sensor domains (VSDs). Disruption of VSD function can cause neurological disease such as epilepsy. READ MORE

7. 5. Voltage sensor movements in shaker and HCN channels

   Author : Roope Männikkö; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, and an ion-conducting pore domain, S5-S6. READ MORE