Search for dissertations about: "weight change"

Showing result 11 - 15 of 370 swedish dissertations containing the words weight change.

  2. 11. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression

    Author : Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE

  4. 12. Incidence trends and environmental determinants of type 1 diabetes in Lithuania and Sweden

    Author : Auste Pundziute-Lyckå; Gisela Dahlquist; Brone Urbonaite; Hans Kristian Åkerblom; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; type 1 diabetes mellitus; epidemiology; childhood; incidence; secular trend; case-control study; risk factors; infections; energy; weight; Pediatrik; Paediatric medicine; Pediatrisk medicin; pediatrik; Pediatrics;

    Abstract : Variation of diabetes incidence over time in countries with different incidence levels and socio-economic conditions, and in an age span beyond the childhood years, may give clues for diabetes causes.Materials: Data from prospective type 1 diabetes registers in Sweden and Lithuania in children (0-14 years) and young adults (15-34 and 15-39 years, respectively). READ MORE

  5. 13. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Author : Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. READ MORE

  6. 14. Blood pressure, blood pressure development and potential risk factors for hypertension with special reference to metabolic factors and kidney function

    Author : Karl Kristjansson; Göteborgs universitet; []
    Keywords : hypertension; blood pressure; women; epidemiology; weight change; metabolic factors; insulin; glucose tolerance; albuminuria; proteinuria; risk factors.;

    Abstract : Objectives: The overall aim of this thesis was to search for predictors of blood pressure development with special reference to anthropometric, metabolic and renal function variables.Study populations and methods: Two large long-term prospective population studies, The Population Study of Women in Gothenburg, Sweden carried out since 1968-69, with 1462 women between 38 and 60 years old at baseline and 24 year follow-up, and The Reykjavik Study, Iceland, which started in 1967 with an initial participation of 8285 men and 9183 women in various age groups. READ MORE

  7. 15. Evaluating energy efficient buildings : Energy- and moisture performance considering future climate change

    Author : Björn Berggren; Institutionen för arkitektur och byggd miljö; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Net Zero Energy Building; passive house; thermal bridge; building envelope; energy performance; moisture performance; multi criteria decision making; climate change; climate scenarios; EN ISO 13789; EN ISO 10211;

    Abstract : One of the greatest challenges the world is facing is climate change. The need of reduction of energy use and an increased use of renewable energy in buildings constitutes important climate change mitigation measures. READ MORE