Search for dissertations about: "whole genome amplification"

Showing result 26 - 30 of 30 swedish dissertations containing the words whole genome amplification.

  2. 26. Developing methods for mapping genetic heterogeneity in tumors : from bulk to single-cell resolution

    Author : Michele Simonetti; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumors are complex ecosystems composed of billions of cells that constantly evolve over time. Intra-tumor heterogeneity (ITH) represents the diversity of this complex environment quantifiable both at the genetic and phenotypic level. Recently, next-generation sequencing (NGS) costs have dropped and NGS has become the standard tool for studying ITH. READ MORE

  4. 27. Predictive Markers of Treatment Resistance in Head and Neck Squamous Cell Carcinoma

    Author : Fredrik Jerhammar; Karin Roberg; Roland Grafström; Agneta Jansson; Keith D. Hunter; Linköpings universitet; []
    Keywords : ;

    Abstract : Head and neck cancer is a common malignancy with approximately 600 000 new cases yearly. Disappointingly, the overall survival has not increased over the last decades. The concept of personalized medicine, i.e. READ MORE

  5. 28. Investigating novel mechanisms for transcriptional memory using genetic engineering

    Author : Yerma Pareja Sanchez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transcriptional memory is phenomenon that has gained interest due to its potential impact on human health. With our work, we wanted to contribute to the understanding of its regulation. To do so, we performed genome-wide knockout screens in both budding yeast and human cells. READ MORE

  6. 29. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

    Author : Jian Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

    Abstract : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. READ MORE

  7. 30. Extremely drug resistant E. coli and K. pneumoniae : novel approaches against their spread and related infections

    Author : Angela Camporeale; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Antibiotic resistance in Enterobacteriaceae is a well-established hindrance and the spread of pathogenic high-risk clones harboring extended-spectrum -lactamases (ESBLs) and carbapenemases is posing a global health challenge, due to very less treatment alternatives. Particular lineages from the major representative species E. coli and K. READ MORE