Search for dissertations about: "whole genome gene expression"

Showing result 1 - 5 of 115 swedish dissertations containing the words whole genome gene expression.

  2. 1. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome

    Author : Husen Muhammad Umer; Jan Komorowski; Claes Wadelius; Jan Korbel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

    Abstract : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. READ MORE

  4. 2. Nonlinear dimensionality reduction of gene expression data

    Author : Jens Nilsson; Matematik LTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Gene expression; Manifold learning; Nonlinear dimensionality reduction; Microarray;

    Abstract : Using microarray measurements techniques, it is possible to measure the activity of genes simultaneously across the whole genome. Since genes influence each others activity levels through complex regulatory networks, such gene expression measurements are state samples of a dynamical system. READ MORE

  5. 3. Evolution of Vertebrate Vision by Means of Whole Genome Duplications : Zebrafish as a Model for Gene Specialisation

    Author : David Lagman; Dan Larhammar; Xesús M Abalo; Finn Hallböök; Stephan Neuhauss; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; evolution; vision; visual opsin; transducin; PDE6; genome duplications; subfunctionalisation; Medicinsk vetenskap; Medical Science;

    Abstract : The signalling cascade of rods and cones use different but related protein components. Rods and cones, emerged in the common ancestor of vertebrates around 500 million years ago around when two whole genome duplications took place, named 1R and 2R. READ MORE

  6. 4. Animal genomics – gene discovery and gene characterization

    Author : Rakan Naboulsi; Leif Andersson; Mårten Larsson; Susanne Kerje; Tosso Leeb; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spontaneous autoimmune thyroiditis; SAT; Hashimoto’s thyroiditis; HT; Obese strain; transcriptional regulation; ZBED6; Igf2; miRNA; miR483; Whole-genome sequencing; RNA-seq; miRNA-seq;

    Abstract : This thesis involves two projects. The aim in the first project was to identify genomic regions associated with spontaneous autoimmune thyroiditis (SAT), which is a hereditary autoimmune disease that affects the obese strain (OS) of chicken, an animal model for human Hashimoto’s thyroiditis (HT). READ MORE

  7. 5. The mitoribosome as a hub for integrating mitochondrial gene expression : Regulation of translation and early assembly of cytochrome b

    Author : Andreas Carlström; Martin Ott; Chris Meisinger; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; gene expression; mitochondrial ribosome; translation regulation; feedback loop; biokemi; Biochemistry;

    Abstract : The mitochondrial proteome is a mosaic of proteins from two different genetic systems. The majority of mitochondrial proteins are encoded in the nuclear genome and are synthesized in the cytosol before imported to mitochondria. READ MORE