Search for dissertations about: "whole genome sequence"

Showing result 1 - 5 of 76 swedish dissertations containing the words whole genome sequence.

  2. 1. Technologies for Single Cell Genome Analysis

    Author : Erik Borgström; Afshin Ahmadian; Sten Linnarsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA; sequencing; single molecule; single cell; whole genome amplification; exome sequencing; emulsions; barcoding; phasin; Biotechnology; Bioteknologi;

    Abstract : During the last decade high throughput DNA sequencing of single cells has evolved from an idea to one of the most high profile fields of research. Much of this development has been possible due to the dramatic reduction in costs for massively parallel sequencing. READ MORE

  4. 2. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    Author : Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
    Keywords : Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Abstract : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. READ MORE

  5. 3. Methods for Analysis of Disease Associated Genomic Sequence Variation

    Author : Lovisa Lovmar; Ann-Christine Syvänen; Pui-Yan Kwok; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; microarray; molecular medicine; single nucleotide polymorphism; whole genome amplification; breast cancer; endometrial cancer; human rotavirus; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ;

    Abstract : In Molecular Medicine a wide range of methods are applied to analyze the genome to find genetic predictors of human disease. Apart from predisposing disease, genetic variations may also serve as genetic markers in the search for factors underlying complex diseases. READ MORE

  6. 4. Rates and patterns of genome evolution in Lepidoptera

    Author : Karin Näsvall; Niclas Backström; Simon Martin; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chromosomal rearrangements; karyotype evolution; recombination rate; Lepidoptera; genome structure; molecular evolution; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : The evolutionary consequences of genome restructuring and chromosomal rearrangements can be significant, but the underlying mechanisms are poorly understood. This thesis explores the relationships between genome restructuring, recombination, and maintenance of genetic diversity in different butterfly species. READ MORE

  7. 5. Exploring genetic diversity in natural and domestic populations through next generation sequencing

    Author : Nima Rafati; Leif Andersson; Carl-Johan Rubin; Alvaro Martinez Bario; Craig Primmer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ecological adaptation; seasonal reproduction; Atlantic herring; domestication; speciation; rabbit; skeletal atavism; Shetland ponies; NGS; SMRT sequencing; genome; transcriptome; assembly; structural variation; genetic diversity; HCE; TSHR; SHOX; CRLF2;

    Abstract : Studying genetic diversity in natural and domestic populations is of major importance in evolutionary biology. The recent advent of next generation sequencing (NGS) technologies has dramatically changed the scope of these studies, enabling researchers to study genetic diversity in a whole-genome context. READ MORE