Search for dissertations about: "whole genomic DNA probes"

Found 4 swedish dissertations containing the words whole genomic DNA probes.

2. 1. Molecular analysis of the oral microbiota of dental diseases

   Author : Eleni Kanasi; Sirkka Asikainen; Anne CR Tanner; Ingegerd Johansson; Gunnar Dahlén; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; early childhood caries; early periodontitis; 16S rDNA cloning and sequencing; whole genomic DNA probes; oligonucleotide DNA probes; PCR; diversity; molecular; aggregatibacter actinomycetemcomitans; serotypes; Oral microbiology; Oral mikrobiologi;

   Abstract : Traditionally, bacterial culture has been used for bacterial detection, allowing study of living microorganisms. Molecular methods are rapid and allow simultaneous identification of numerous species and uncultivated phylotypes. READ MORE

4. 2. Extracting Genomic Variations using Selector Technology

   Author : Magnus Isaksson; Mats Nilsson; Radoje Drmanac; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Selector; Selector probe; Genetic variation; Resequencing; Targeted sequencing; copy-number variations; MLGA; Bioinformatics; Next generation sequencing; NGS; Amplified single molecule; ASM; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Genetics; Genetik; Molekylär medicin; Molecular Medicine;

   Abstract : This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. READ MORE

5. 3. The female genital tract microbiota: composition, relation to innate immune factors, and effects of contraceptives

   Author : Natalia Nikolaitchouk; Göteborgs universitet; []
   Keywords : bacterial vaginosis; checkerboard DNA-DNA hybridisation; cytokines; SLPI; Lactobacillus coleohominis; Lactobacillus iners; Actinomyces urogenitalis;

   Abstract : Abnormal vaginal microbiota, as in bacterial vaginosis (BV), is associated with increased risk of obstetrical and gynaecologic complications and acquisition of sexually transmitted diseases. However, very little is known about the pathogenesis of BV. In BV, the normal vaginal Lactobacillus-dominated biota (LDB) is replaced by anaerobic bacteria. READ MORE

6. 4. Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome

   Author : Chen Suo; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) is transcribed to messenger ribonucleic acid (mRNA), and then translated into proteins; dysfunction in any of these processes may contribute to the development of disease. READ MORE