Search for dissertations about: "wortmannin"

Showing result 1 - 5 of 17 swedish dissertations containing the word wortmannin.

  1. 1. Phosphatidylinositol 4-kinases in plasma membranes and Affinity partitioning of liposomes: a model system for membrane purification

    University dissertation from Biochemistry, Center for Chemistry and Chemical Engineering, Lund University

    Author : Lars Ekblad; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; metabolism; Biokemi;

    Abstract : Polyphosphoinositides, the different phosphorylated variants of the phospholipid phosphatidylinositol (PtdIns), are used in a wide array of intracellular mechanisms in eukaryotic cells. The phosphorylation of PtdIns at carbon D4, catalyzed by phosphatidylinositol 4-kinase, is an important step in the synthesis of several of these molecules. READ MORE

  2. 2. Apoptosis, cellular division or mitotic catastrophe? : effects of kinase inhibition and DNa damage in lung cancer cells

    University dissertation from Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Author : Anna Therése Helén Hemström; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Non-small cell lung cancer (NSCLC) cells are generally characterized by a low response to conventional anti-cancer agents, such as DNA-damaging drugs. Treatments that induce DNA damage relies on cellular signalling resulting in the induction of growth arrest and apoptotic cell death. READ MORE

  3. 3. Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine and Surgery

    Author : Olga Kotova; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Na ; K -ATPase; insulin; C-peptide; exercise; in vitro contraction; cardiotonic steroids; ouabain; marinobufagenin; ERK 1 2 MAP kinase; Src; p90 rsk; GSK3; signaling cascade; glycogen synthesis; human skeletal muscle cells; human renal tubular cells; rat skeletal muscle.;

    Abstract : Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells (HSMCs) and primary human renal tubular cells (HRTCs) was determined. READ MORE

  4. 4. Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Author : Jie Chen; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein-tyrosine phosphatase; insulin; glucagon; vanadate; type 2 diabetes; pancreatic islets;

    Abstract : Both insulin and glucagon secretion from pancreatic beta- and alpha-cells, respectively, are regulated by nutrients such as glucose and amino acids. In addition, the mechanisms leading to exocytosis of hormones are influenced by kinases and phosphatases that phosphorylate and dephosphorylate regulatory proteins respectively. READ MORE

  5. 5. Mechanisms of Tissue Vascularization

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Witold Kilarski; Pär Gerwins; Lena Claesson-Welsh; Andreas Bikfalvi; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; vascularization; angiogenesis; granulation tissue; myofibroblast; wound healing; Patologi; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Abstract : Tissue neovascularization in postnatal life occurs during post-traumatic tissue healing, neoplastic growth and in the endometrium during the reproductive cycle of females. Although embryonic angiogenesis has been intensively studied, far less is known about tissue revascularization and vessel remodeling in adults due to methodological difficulties. READ MORE