Search for dissertations about: "wortmannin"

Showing result 11 - 15 of 18 swedish dissertations containing the word wortmannin.

  2. 11. On the Regulation of the Epithelial Paracellular Permeability

    Author : Pia Nybom; Janove Sehlin; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The epithelia of for instance the small intestine(s) plays a crucial role in the vectorial transport of nutrients and other solutes from the lumen to underlying body fluids, i.e. blood and lymph. READ MORE

  4. 12. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

    Author : Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

    Abstract : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. READ MORE

  5. 13. Mechanistic studies of APR-246 in leukemia

    Author : Dina Mahmoud Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. READ MORE

  6. 14. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

    Author : Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

    Abstract : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). READ MORE

  7. 15. Role of inositol pyrophosphates in pancreatic beta cell function

    Author : Subu Surendran Rajasekaran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ribosome synthesis, cell cycle regulation and apoptosis to osmoregulation, phosphate homeostasis, insulin sensitivity, vesicle trafficking, cytoskeletal rearrangement and exocytosis. READ MORE