Search for dissertations about: "wortmannin"

Showing result 6 - 10 of 18 swedish dissertations containing the word wortmannin.

  2. 6. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes

    Author : Martin Ridderstråle; Diabetes - klinisk obesitasforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin receptor substrate-1; insulin receptor substrate-2 phosphatidylinositol 3-kinase; signal transducer and activator of transcription 5; janus kinase 2; phosphotyrosine; receptor; phosphorylation; Growth hormone; Metabolism; Biochemistry; rat; adipocyte; lipolysis; lipogenesis; Biokemi; metabolism; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. READ MORE

  4. 7. Signalling to Activation of Cytosolic Phospholipase A2 and Arachidonate Release in Macrophages

    Author : Gösta Hiller; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; signal transduction; dexamethasone; macrophages; phospholipase C; phosphatidylinositol 3-kinase; mitogen-activated protein kinases; cytosolic phospholipase A2; arachidonic acid; Histology; cytochemistry; histokemi; cytokemi; tissue culture; Histologi; vävnadskultur; histochemistry;

    Abstract : Eicosanoids include prostaglandins, thromboxanes and leukotrienes, which are arachidonic acid oxygenation products. These lipids make important contributions to the signs and symptoms of inflammatory diseases. READ MORE

  5. 8. Vascular endothelial growth factor receptors in angiogenesis

    Author : Kui Huang; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; endothelial cells; VEGF receptor; signal transduction; pertide; angiogenesis; Genetik; Clinical genetics; Klinisk genetik; Medical Biochemistry; medicinsk biokemi;

    Abstract : Angiogenesis is a process in which new capillaries sprout from preexisting blood vessels. Vascular endothelial growth factor (VEGF) promotes endothelial cell proliferation and migration and thereby stimulates angiogenesis. VEGF receptors (VEGFRs) have been implicated as key regulatory components in endothelial cells. READ MORE

  6. 9. Eosinophil Inflammation in Allergic Disease : Clinical and experimental studies in allergic asthma and allergic rhinitis

    Author : Mary Kämpe; Marie Carlson; Christer Janson; Gunnemar Stålenheim; Magnus Sköld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergic asthma; allergic rhinitis; eosinophils; pollen season; bronchial challenge; nasal challenge eosinophil degranulation; PI3K signalling; Allergology; Allergologi; Lung Medicine; Lungmedicin; Lung Medicine; Lungmedicin;

    Abstract : Allergic diseases are chronic inflammatory conditions, characterised by eosinophil inflammation systemically and in target organs, where cytotoxic granule proteins are responsible for tissue injury. Allergic rhinitis is known to be a risk factor for the development of asthma, yet not all with rhinitis develop asthma. READ MORE

  7. 10. Signal transduction pathways involved in PDGF receptor-induced cellular responses

    Author : Roya Hooshmand-Rad; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Platelet-derived growth factor (PDGF), is a potent connective tissue cell mitogen and chemoattractant which binds to two structurally related receptors denoted PDGF α- and β- receptors. Upon binding of PDGF to the receptor, signaling molecules containing Src Homology 2 (SH2) domains are recruited to the activated receptor and mediate propagation of the signal. READ MORE