Search for dissertations about: "xenotransplantation diabetes"
Showing result 1 - 5 of 10 swedish dissertations containing the words xenotransplantation diabetes.
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1. Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation
Abstract : In the field of transplantation, the increasing deficit of human donors have lead to an interest in animals as an alternative source of organs and tissues. Different in vitro systems and rodent models of xenotransplantation were used to examine the most significant barriers that have to be overcome, before isolated islets of Langerhans from pigs can be used as a cure for insulin-dependent diabetes mellitus in humans. READ MORE
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2. Studies of Innate and Adaptive Immunity in Islet Transplantation
Abstract : Clinical islet transplantation is today an established alternative treatment for a selected group of type 1 diabetes patients. The predominant technique for transplantation is infusion of islets in the liver via the portal vein. READ MORE
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3. Xenograft Rejection : A Study of Cytokine mRNA Expression in Experimental Models
Abstract : Acute cellular xenograft rejection of ICCs triggered mRNA expression of proinflammatory cytokines (IL-1b and TNF-a), Th1 associated cytokines (IL-12p40, IL-2 and IFN-g) and Th2 associated cytokines (IL-4 and IL-10). The peak values and the kinetics of the mRNA expression indicated that acute cellular xenograft rejection is enhanced by the proinflammatory response and mediated by the Th1 associated response, whereas the function of the Th2 associated response most likely is to counteract the Th1 associated cytokines and thereby inhibit bystander damage by the delayed type hypersensitivity like rejection process. READ MORE
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4. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell
Abstract : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. READ MORE
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5. Xenotransplantation of fetal porcine islet-like cell clusters in diabetes mellitus : an experimental and clinical study
Abstract : .... READ MORE