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Showing result 1 - 5 of 42 swedish dissertations matching the above criteria.
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1. Complex Trait Genetics : Beyond Additivity
Abstract : The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. READ MORE
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2. Factors modulating tRNA biogenesis and function in Saccharomyces cerevisiae
Abstract : Transfer RNA (tRNA) genes are transcribed by RNA polymerase III as precursors that undergo multiple processing steps to form mature tRNAs. These steps include processing of the 5’ leader and 3’ trailer sequences, addition of a 3’ CCA tail, removal of introns, and formation of modified nucleosides. READ MORE
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3. Functional organisation of the cell nucleus in the fission yeast, Schizosaccharomyces pombe
Abstract : In eukaryotes the genome adopts a non-random spatial organisation, which is important for gene regulation. However, very little is known about the driving forces behind nuclear organisation. READ MORE
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4. Studies of Budding Yeast Transcription Factors Acting Downstream of Nutrient Signaling Pathways
Abstract : Being able to respond to extracellular cues such as nutrients and growth factors is of vital importance to all living cells. Pathways have therefore evolved which can sense the extracellular status, transmit a signal through the cell and affect gene expression, which ultimately enables adaptation. READ MORE
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5. Systems Biology of Yeast Lipid Metabolism
Abstract : Lipid metabolism plays an important role in the development of many different life-style related diseases, such as type 2 diabetes and atherosclerosis, and understanding the molecular mechanisms behind regulation of lipid biosynthesis and degradation may lead to development of new therapies. In this project we undertook a global study of lipid metabolism in the eukaryotic model organism Saccharomyces cerevisiae. READ MORE