Search for dissertations about: "zebrafish models"

Showing result 1 - 5 of 39 swedish dissertations containing the words zebrafish models.

2. 1. New targeted therapies for malignant neural tumors : From systematic discovery to zebrafish models

   Author : Elin Almstedt; Sven Nelander; Rogier Versteeg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; glioblastoma; data integration; zebrafish models; precision medicine; Oncology; Onkologi; Medical Cell Biology; Medicinsk cellbiologi; Medical Informatics; Medicinsk informatik; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Molekylär medicin; Molecular Medicine;

   Abstract : Cancers in the neural system presents a major health challenge. The most aggressive brain tumor in adults, glioblastoma, has a median survival of 15 months and few therapeutic options. High-risk neuroblastoma, a childhood tumor originating in the sympathetic nervous system, has a 5-year survival under 50%, despite extensive therapy. READ MORE

4. 2. Genetic studies of zebrafish muscles : clues to protection in muscle disease

   Author : Nils Dennhag; Fatima Pedrosa Domellöf; Jonas von Hofsten; Tatjana Haitina; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; muscle; extraocular muscles; intermediate filaments; bioinformatics; genetics; CRISPR Cas9; oftalmiatrik; ophthalmology; cellforskning; cell research;

   Abstract : Muscular dystrophies (MDs) are caused by dysregulation of over 40 proteins but commonly share features of muscle weakness, myofiber death and regeneration, loss of ambulation and premature death. A MD involves a broken link anywhere in the connection from extracellular matrix through the sarcolemma to the sarcomere. READ MORE

5. 3. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

   Author : Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

   Abstract : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. READ MORE

6. 4. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)

   Author : Ioana C. Chelcea; Patrik L. Andersson; Timo Hamers; Jessica Legradi; Stefan Örn; Carolina Vogs; Nynke Kramer; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PBTK; Toxicokinetics; Endocrine disruptors; bisphenols; zebrafish; embryo; Toxicology; toxikologi;

   Abstract : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. READ MORE

7. 5. Cell-based models for studying paediatric high-grade gliomas

   Author : Susanna Larsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; paediatric brain tumour; glioblastoma; glioma stem cell; primary culture; xenograft tumour; zebrafish;

   Abstract : Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one of the most devastating forms with very poor prognosis due to lack of efficient treatments. READ MORE