Search for dissertations about: "zebrafish"

Showing result 1 - 5 of 137 swedish dissertations containing the word zebrafish.

  1. 1. Translating Cardiac and Cardiometabolic GWAS Using Zebrafish

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Benedikt von der Heyde; Marcel den Hoed; Anastasia Emmanouilidou; Erik Ingelsson; Shawn Burgess; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Zebrafish; Medicinsk genetik; Medical Genetics;

    Abstract : Genome-wide association studies (GWAS) have identified thousands of loci associated with cardiac and cardiometabolic traits. However, the trait-associated variants usually do not clearly point to causal gene(s), mechanism(s) or tissue(s). Model systems that allow for a comprehensive and quick candidate gene screening are necessary, ideally in vivo. READ MORE

  2. 2. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis Validation and application

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

    Abstract : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. READ MORE

  3. 3. Studies of the Neuropeptide Y Receptor Y2 in Human and Zebrafish

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Helena Fällmar; Dan Larhammar; Ingrid Lundell; Nina Mohell; Raquel E. Rodríguez Rodríguez; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Y2-receptor; NPY; PYY; G-protein-coupled receptor; mutagenesis; receptor binding; zebrafish; evolution; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi; Farmakologi; Pharmacology;

    Abstract : The G-protein coupled receptors (GPCRs) comprise the largest family of receptors in humans and other vertebrates. They are embedded in the cell membrane and are activated by many different signaling molecules. Activation modulates cellular signal transduction pathways and influences many physiological processes. READ MORE

  4. 4. Developmental exposure to mixtures of environmental pollutants Studies on metabolism, developmental processes, and reproductive organs in zebrafish and chicken embryos

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Mentor; Maria Jönsson; Patrick Babin; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mixtures; Developmental toxicology; Endocrine disrupting chemicals; Metabolism; Feminization; Zebrafish; Chicken embryo; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : Humans and wildlife are continuously exposed to mixtures of environmental pollutants. Mixture toxicity can be challenging to predict due to interactions between chemicals and thus whole-mixture approaches are crucial in toxicology. READ MORE

  5. 5. New targeted therapies for malignant neural tumors From systematic discovery to zebrafish models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elin Almstedt; Sven Nelander; Rogier Versteeg; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; glioblastoma; data integration; zebrafish models; precision medicine; Oncology; Onkologi; Medical Cell Biology; Medicinsk cellbiologi; Medical Informatics; Medicinsk informatik; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Molekylär medicin; Molecular Medicine;

    Abstract : Cancers in the neural system presents a major health challenge. The most aggressive brain tumor in adults, glioblastoma, has a median survival of 15 months and few therapeutic options. High-risk neuroblastoma, a childhood tumor originating in the sympathetic nervous system, has a 5-year survival under 50%, despite extensive therapy. READ MORE