Search for dissertations about: "zebrafish"

Showing result 1 - 5 of 132 swedish dissertations containing the word zebrafish.

  1. 1. Translating Cardiac and Cardiometabolic GWAS Using Zebrafish

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Benedikt von der Heyde; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Zebrafish; Medicinsk genetik; Medical Genetics;

    Abstract : Genome-wide association studies (GWAS) have identified thousands of loci associated with cardiac and cardiometabolic traits. However, the trait-associated variants usually do not clearly point to causal gene(s), mechanism(s) or tissue(s). Model systems that allow for a comprehensive and quick candidate gene screening are necessary, ideally in vivo. READ MORE

  2. 2. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis Validation and application

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Manoj Kumar Bandaru; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

    Abstract : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. READ MORE

  3. 3. Studies of the Neuropeptide Y Receptor Y2 in Human and Zebrafish

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Helena Fällmar; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Y2-receptor; NPY; PYY; G-protein-coupled receptor; mutagenesis; receptor binding; zebrafish; evolution; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi; Farmakologi; Pharmacology;

    Abstract : The G-protein coupled receptors (GPCRs) comprise the largest family of receptors in humans and other vertebrates. They are embedded in the cell membrane and are activated by many different signaling molecules. Activation modulates cellular signal transduction pathways and influences many physiological processes. READ MORE

  4. 4. Hitting the mark studies of alterations in behaviour and fertility in ethinyl estradiol-exposed zebrafish and search related biomarkers

    University dissertation from Örebro : Örebro university

    Author : Nasim Reyhanian Caspillo; Örebro universitet.; Södertörns högskola.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Endocrine disrupting compounds; 17α-ethinylestradiol; fertility; anxiety; behaviour; zebrafish; biomarkers; stress;

    Abstract : In this thesis, we have analysed the effects of EE2 on non-reproductive behaviours and fertility. We have showed that two doses of EE2 in male adult short-term exposures evokes opposite behaviours in the novel tank test. READ MORE

  5. 5. Glycosaminoglycan Biosynthesis in Zebrafish

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Beata Filipek-Górniok; Uppsala universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; chondroitin dermatan sulfate; biosynthesis; development; N-deacetylase N-sulfotransferase; glycosyltransferases; morpholino; CRISPR-Cas9;

    Abstract : Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. READ MORE