Search for dissertations about: "zinc finger protein"

Showing result 1 - 5 of 47 swedish dissertations containing the words zinc finger protein.

2. 1. Three Subfamilies of KRAB Zinc Finger Proteins : A Structural, Functional and Evolutionary Analysis

   Author : Charlotta Mark; Lars Hellman; Fredrik Öberg; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Krüppel zinc finger; KRAB; TIF1β; transcriptional repression; Biologi; Biology; Biologi; Molecular Immunology; molekylär immunologi;

   Abstract : Krüppel-related zinc finger proteins constitute the largest single class of transcription factors within the human genome. Members of this protein family have the ability to either activate or repress transcription depending on the presence of specific activator or repressor domains within the protein. READ MORE

4. 2. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

   Author : Elmar Nurmemmedov; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

   Abstract : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. READ MORE

5. 3. Human adenovirus – host cell interplay : The role of the cellular zinc finger proteins and mitochondrial DNA

   Author : Kwangchol Mun; Tanel Punga; Stefan Schwartz; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Adenovirus; Protein VII; Ubiquitination; Chromatin remodeling; Mitochondria;

   Abstract : Human adenovirus (HAdV) is an abundant DNA virus with significant clinical relevance since it cauces a variety of respiratory, ocular, and gastrointestinal diseases. It is also intensively used as a therapeutic tool to treat cancers and to boost immune responses. READ MORE

6. 4. Molecular studies of Wig-1, a p53-induced zinc finger protein

   Author : Cristina Méndez Vidal; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The fact that p53 is one of the most commonly mutated gene in human tumors indicates that it has a key role in tumor suppression. p53 accumulates after DNA-damage and other types of cellular stress, leading to the initiation of a p53-dependent biological response, including cell cycle arrest and apoptosis. READ MORE

7. 5. Structural and Functional Studies of the Wilms' Tumour 1 Protein (WT1) in Interaction with Nucleic acids

   Author : Raymond Yengo Kimbung; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; WT1; Zinc finger; Structure; Transcription factor;

   Abstract : The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney malignancy, Wilms’ tumour. READ MORE