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Showing result 1 - 5 of 50 swedish dissertations matching the above criteria.

  2. 1. The ABC of KRAB zinc finger proteins

    Author : Camilla Looman; Lars Hellman; Lars-Gunnar Larsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Krüppel zinc finger; KRAB; transcription; repression; evolution; Biologi; Biology; Biologi; immunologi; Immunology;

    Abstract : All living organisms consist of cells and the identity of a cell is defined by the genes it expresses. To assure proper function, a cell receives continuous information on which genes to turn on and off. This information is, to a large extent, provided by transcription factors. READ MORE

  4. 2. Three Subfamilies of KRAB Zinc Finger Proteins : A Structural, Functional and Evolutionary Analysis

    Author : Charlotta Mark; Lars Hellman; Fredrik Öberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Krüppel zinc finger; KRAB; TIF1β; transcriptional repression; Biologi; Biology; Biologi; Molecular Immunology; molekylär immunologi;

    Abstract : Krüppel-related zinc finger proteins constitute the largest single class of transcription factors within the human genome. Members of this protein family have the ability to either activate or repress transcription depending on the presence of specific activator or repressor domains within the protein. READ MORE

  5. 3. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

    Author : Elmar Nurmemmedov; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

    Abstract : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. READ MORE

  6. 4. Structural and functional analysis of KRAB zinc finger genes

    Author : C Mark; Uppsala universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  7. 5. Structural and Functional Studies of the Wilms' Tumour 1 Protein (WT1) in Interaction with Nucleic acids

    Author : Raymond Yengo Kimbung; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; WT1; Zinc finger; Structure; Transcription factor;

    Abstract : The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney malignancy, Wilms’ tumour. READ MORE