Search for dissertations about: "zinc finger"

Showing result 16 - 20 of 50 swedish dissertations containing the words zinc finger.

  2. 16. Identification, cloning and characterization of the p53 induced gene human Wig-1

    Author : Fredrik Hellborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 is a transcription factor that responds to various kinds of cellular stress. In respons to the sensed stress it is able to induces cell cycle arrest and apoptosis. In order to achieve these effects it transactivates target genes. READ MORE

  4. 17. The functional organization of nuclear envelope proteins

    Author : Santhosh Kumar Gudise; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In eukaryotic cells, the nucleus is enclosed by a double lipid membrane, termed the nuclear envelope (NE). The NE consists of the outer nuclear membrane (ONM), the inner nuclear membrane (INM), the nuclear pore complexes (NPCs) and the nuclear lamina. READ MORE

  5. 18. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Author : Emelie Svensson; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; Cofilin 1; NDRG2; IRF-8; BCR ABL1; hematopoiesis; Wilms´ tumor gene 1; leukemia;

    Abstract : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. READ MORE

  6. 19. Transcriptional Silencing in the Imprinted Igf2-H19 Loci: The Mystique of Epigenetics

    Author : Vasudeva Ginjala; Andreas Paldi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; DNA methylation; IGF2-H19; CTCF; ZFPs; PARP; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Genetics; genetik;

    Abstract : Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoallelic expression in a non-Mendelian fashion. To restore totipotency and to reset the imprint according to the sex of the individual, the mark must be erased during germline development. READ MORE

  7. 20. Molecular mechanisms of alternative estrogen receptor signaling

    Author : Linda Björnström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptor a (ERalpha) and estrogen receptor beta (ERbeta), which belong to a large superfamily of nuclear receptors that act as ligand-activated transcription factors. READ MORE