Resistance to phagocytosis in Streptococcus pyogenes

University dissertation from Dept of Laboratory Medicine, Div of Medical Microbiology, Lund University

Author: Fredric Carlsson; Lunds Universitet.; Lund University.; [2005]

Keywords: MEDICIN; MEDICINE; Infections Infektioner Medicine human and vertebrates Medicin människa och djur phagocytosis innate immunity complement Streptococcus pyogenes M protein;

Abstract: Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M proteins of different M type.

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