Histamine and chromogranin A-derived peptides in rat stomach ECL cells

University dissertation from Per Norlén, Dept. of Pharmacol. Sölveg. 10, S-22362 Lund, Sweden

Author: Per Norlén; Lunds Universitet.; Lund University.; [2000]

Keywords: MEDICIN; MEDICINE; pharmacognosy pharmacy Pharmacological sciences CGRP adrenaline galanin VIP PACAP somatostatin gastrin microdialys pancreastatin chromogranin A histamine ECL cell rat stomach toxicology Farmakologi farmakognosi farmaci toxikologi Endocrinology secreting systems diabetology Endokrinologi sekretion diabetologi;

Abstract: The ECL cells constitute the predominant endocrine cell population of the stomach. They secrete histamine which is a major stimulator of acid secretion. Chormogranin A (CgA)-derived peptides, such as pancreastatin, are co-secreted with histamine. In this thesis it was demonstrated that pancreastatin may serve as a reliable marker for ECL cell secretory activity in the rat. The function of pancreastatin and other CgA-derived peptides is however obscure, and therefore, attempts were made to develop a method for continuous monitoring of ECL-cell histamine in conscious rats. By using microdialysis it was demonstrated that histamine is secreted from ECL cells in response to gastrin and food and to a number of neuropeptides, such as PACAP, VIP and adrenaline. It could also be demonstrated that anaesthesia greatly impairs ECL-cell histamine secretion.

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