Search for dissertations about: "xrcc1"

Showing result 1 - 5 of 10 swedish dissertations containing the word xrcc1.

  2. 1. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1

    Author : Cecilia Ström; Thomas Helleday; Hans Krokan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; base excision repair; single-strand break repair; PARP-1; CK2; XRCC1; mammalian cells; Cell and molecular biology; Cell- och molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Abstract : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. READ MORE

  4. 2. Post-translational modifications of XRCC1 by the protein kinase CK2

    Author : Cecilia Ström; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  5. 3. Induction and repair of DNA double-strand breaks in human cells exposed to different radiation qualities

    Author : Irina Radulescu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DSB; chromatin structure; high-LET; heat-labile sites; PFGE; DNA-PKcs; XRCC1; PARP-1; pATM; gamma-H2AX; 53BP1;

    Abstract : Radiation therapy is used in attempting to kill tumor cells by inducing DNA double- strand breaks (DSB), the most critical DNA lesions. Recent and planned radiation therapy strategies use high-linear energy transfer (LET) radiation to effectively treat malignant tumors. READ MORE

  6. 4. Genes and brain tumors

    Author : Maral Adel Fahmideh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Although brain tumors are rare and combined with other nervous system tumors account for ~ 2% of all cancers, they are the second most common type of pediatric cancer. The etiology of brain tumors, known as multifactorial traits, is poorly understood. READ MORE

  7. 5. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks

    Author : Karin Karlsson; Bo Stenerlöw; Jörgen Carlsson; Thomas Helleday; Uppsala universitet; []
    Keywords : Molecular biology; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionising radiation; high-LET; heat-labile sites; PFGE; Molekylärbiologi;

    Abstract : Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual cells and organisms. Defects in the DNA repair may lead to cell death or genomic instability and development of cancer. READ MORE