Search for dissertations about: "Claes Wadelius"
Showing result 1 - 5 of 14 swedish dissertations containing the words Claes Wadelius.
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1. Molecular studies of genes and mutations in families with genetic disorders
Abstract : .... READ MORE
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2. A Bioinformatics Study of Human Transcriptional Regulation
Abstract : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. READ MORE
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3. Decoding the Structural Layer of Transcriptional Regulation : Computational Analyses of Chromatin and Chromosomal Aberrations
Abstract : Gene activity is regulated at two separate layers. Through structural and chemical properties of DNA – the primary layer of encoding – local signatures may enable, or disable, the binding of proteins or complexes of them with regulatory potential to the DNA. READ MORE
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4. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development
Abstract : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. READ MORE
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5. Genome-Wide Studies of Transcriptional Regulation in Human Liver Cells by High-throughput Sequencing
Abstract : The human genome contains slightly more than 20 000 genes that are expressed in a tissue specific manner. Transcription factors play a key role in gene regulation. By mapping the transcription factor binding sites genome-wide we can understand their role in different biological processes. READ MORE