Search for dissertations about: "EBV-associated malignancies"

Showing result 1 - 5 of 11 swedish dissertations containing the words EBV-associated malignancies.

2. 1. Mechanisms of immune escape in EBV associated malignancies : Hodgkin's disease and Burkitt's lymphoma

   Author : Teresa Frisan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus; tumor immune escape; antigen presentation; cytotoxic T lymphocytes;

   Abstract : The work presented in this thesis is focused on the analysis of the mechanisms operating in the immune escape of two Epstein-Barr virus (EBV) associated tumors: Hodgkin's Disease (HD) and Burkitt's lymphoma (BL). EBV positive HD tumor cells express at least 3 viral proteins: the EBV nuclear antigen (EBNA)1, the latent membrane proteins (LMP)1 and LMP2A. READ MORE

4. 2. Characterization of Epstein-Barr virus non-coding RNAs in infected cells

   Author : Guojiang Xie; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EBV; EBV-associated malignancies; viral gene expression pattern; RPMS1; EBERs; single-cell sequencing; ChIRP; immune evasion; protein synthesis;

   Abstract : Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial for understanding EBV tumorigenesis. READ MORE

5. 3. EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

   Author : Liudmila Matskova; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus EBV ; Latent membrane protein 2A LMP2A . HECTdomain E3 ubiquitin ligase; Shb signaling scaffold. Akt kinase; Tyrosine phosphorylation.;

   Abstract : Over 90% of the adult human population carries Epstein-Barr Virus (EBV). EBV stays for life, striking a balance with the immune system. The virus evades immune elimination by severely restricting its own gene expression. The latent infection is established with the resting memory type B-cell as the reservoir. READ MORE

6. 4. Control of Epstein-Barr virus infection by cytotoxic T lymphocytes

   Author : Pedro-Otavio de Campos-Lima; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus; Cytotoxic T lymphocytes; T cell receptor; CTLescape mutants;

   Abstract : Cytotoxic T lymphocytes (CTL) play a critical role in response to Epstein-Barr virus (EBV), a widespread human herpes virus that persists in healthy carriers as a latent infection of B cells and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. Six virus encoded nuclear antigens, EBNA1-6, and three membrane proteins, LMP1, -2A and -2B, are regularly detected in EBV transformed lymphoblastoid cell lines (LCLs). READ MORE

7. 5. Characterization of non-coding mRNA in Epstein-Barr virus

   Author : Åsa Isaksson; Göteborgs universitet; []
   Keywords : Epstein-Barr virus; EBNA1; IRES; PTLD; alternative splice; nucleotide substitution; protein interactions;

   Abstract : Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally associated with various malignancies including Burkitt?s lymphoma, Hodgkin?s disease and lymphoproliferative syndromes in immunocompromised individuals. READ MORE