Search for dissertations about: "erythropoietin receptor"

Showing result 1 - 5 of 8 swedish dissertations containing the words erythropoietin receptor.

2. 1. Erythropoiesis in anemia of rencl failure and malignancy : Studies on erythropoietin, iron, and transferrin receptor : by Soheir Beshara

   Author : Soheir Beshara; Uppsala universitet; []
   Keywords : Medical sciences; erythropoiesis; anemia; renal transplantation; prostatic adenocarcinoma; erythropoietin; transferrin receptor; hemorheology positron emission tomography; iron hydroxide sucrose; pharmacokinetics; iron deficiency; 52Fe; 59Fe; red cell utilization; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Internal Medicine; invärtesmedicin;

   Abstract : Erythropoietin (Epo) and iron are essential requirements for erythropoiesis. Serum transferrin receptor (S-TfR) is a marker of total erythropoiesis and tissue iron availability. In patients with renal insufficiency, successful renal transplantation leads to correction of anemia and improvement in erythropoiesis. READ MORE

4. 2. Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer

   Author : Susann Reinbothe; Avdelningen för translationell cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tamoxifen resistance; proliferation; PI3k pathway; Breast cancer; erythropoietin receptor; estrogen receptor;

   Abstract : The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Therefore, recombinant human EPO (rhEPO) is used to treat anemia in cancer patients, but some studies have reported that rhEPO treatment might promote tumor progression. Additionally, EPOR expression has been detected in various cancer forms. READ MORE

5. 3. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

   Author : Anna-Maria Larsson; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Anemia; Hypoxia; Erythropoietin EPO ; EPO receptor EPOR ; Estrogen Receptor ER ; Hypoxia-Inducible Factors HIFs ; Tamoxifen Response; Proliferation;

   Abstract : The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. READ MORE

6. 4. Prognostic factors in renal cell carcinoma : evaluation of erythropoietin and its receptor, carbonic anhydrase IX, parathyroid hormone-related protein and osteopontin

   Author : Karin Papworth; Torgny Rasmuson; Börje Ljungberg; Kjell Grankvist; Sten Nilsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; EPO; EPO-R; CA IX; PTHrP; OPN; prognosis; Oncology; Onkologi; onkologi; Oncology;

   Abstract : A prognostic factor is a marker or a feature that can be used to estimate the risk of recurrence of disease, metastatic spread and clinical outcome. Despite intensive search for more sophisticated markers in renal cell carcinoma (RCC), few have added prognostic information to earlier described factors like stage of disease, nuclear grade, tumour type, and in metastatic disease; performance status, anaemia, hypercalcaemia and increased erythrocyte sedimentation. READ MORE

7. 5. Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets

   Author : Ghazal Efazat; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases are found and only for a limited number of NSCLC tumors targeted therapies can be used as their oncogenic drivers remains elusive. READ MORE