Search for dissertations about: "postnatal development of brain in rats"

Showing result 1 - 5 of 18 swedish dissertations containing the words postnatal development of brain in rats.

2. 1. Proteomic Characterization of Induced Developmental Neurotoxicity

   Author : Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

   Abstract : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. READ MORE

4. 2. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia

   Author : Xiaoyang Wang; Göteborgs universitet; []
   Keywords : hypoxia-ischemia; neonatal; caspase; ERK; XIAP; EPO; asialoEPO; brain;

   Abstract : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. READ MORE

5. 3. Developmental Neurotoxicity in Mice Neonatally Co-exposed to Environmental Agents : PCB, PBDE, Methyl Mercury and Ionized Radiation - Interactions and Effects

   Author : Celia Fischer; Per Eriksson; Anders Fredriksson; Richard Seegal; Uppsala universitet; []
   Keywords : Biology; PCB; PBDE; MeHg; ionized radiation; neonatal; development; neurotoxicity; behavior; cholinergic system; Biologi;

   Abstract : This thesis investigates the neurotoxic effects in mice neonatally co-exposed to different toxic environmental agents during a defined critical period of the brains's rapid growth and development. Environmental toxic agents are incorporated in our environment. READ MORE

6. 4. Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I

   Author : N David Åberg; Göteborgs universitet; []
   Keywords : Connexin43; rat; development; hypophysectomy; primary culture; ; mRNA; gap junction; somatotropin; IGF-I; serotonin; glutamate; ; brain region heterogeneity; calcium wave; astrocyte; astroglial cell; ; gap junctional coupling.;

   Abstract : Connexins form gap junctions that are aqueous pores allowing low-molecular (.... READ MORE

7. 5. Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)

   Author : Henrik Viberg; Per Eriksson; Susan Schantz; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; brominated flame retardants; polybrominated diphenyl ethers; PBDE; neonatal; development; neurotoxicity; behaviour; cholinergic system; Biologi; Biology; Biologi;

   Abstract : This thesis examines developmental neurotoxic effects of polybrominated diphenyl ethers (PBDEs), PBDE 99, PBDE 153, and the fully brominated PBDE 209, after exposure during the newborn period in rodents. Our environment contains vast numbers of contaminants, including the flame retardants, PBDEs. READ MORE