Search for dissertations about: "pH liposomes"

Showing result 1 - 5 of 17 swedish dissertations containing the words pH liposomes.

2. 1. Liposomes for Drug Delivery : from Physico-chemical Studies to Applications

   Author : Nill Bergstrand; Katarina Edwards; Felix M Goni; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; liposome; steric stabilisation; BNCT; cryo-TEM; EGF; targeting; stability; permeability; pH-sensitive liposomes; triggered release; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

   Abstract : Physico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. READ MORE

4. 2. Physico-Chemical Investigations of Bilayer Discs and Related Lipid Structures Formed in Liposomal Systems Intended for Triggered Release

   Author : Maria Sandström; Katarina Edwards; Mats Almgren; Tommy Nylander; Uppsala universitet; []
   Keywords : Physical chemistry; liposome; triggered release; pH-sensitive liposomes; temperature-sensitive liposomes; drug partitioning; cryo-TEM; discs; Fysikalisk kemi;

   Abstract : This thesis describes results from fundamental studies of liposomes intended for drug delivery and pH or temperature triggered release. In addition, the effect of lipid composition on bilayer disc formation and a potential application of the bilayer discs were investigated. READ MORE

5. 3. Structure and stability of liposomes : Interactions with micelle- forming surfactants

   Author : Mats Silvander; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; Fysik; Physics; Fysik; Physical Chemistry; fysikalisk kemi;

   Abstract : The stability of phospholipid lipomes interacting with micelle-forming surfactants was studied under physiological conditions (150 mM NaCl and pH=7.4 unless otherwise stated) mainly by use of cryo-TEM and fluorescence. READ MORE

6. 4. Tailormade Surfaces for Extended CE Applications

   Author : Sara Ullsten; Karin Markides; Staffan Folestad; Gerhardus J de Jong; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis; mass spectrometry; surface properties; coatings; polymers; liposomes; proteins; drugs; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Abstract : The combination of capillary electrophoresis (CE) and mass spectrometry (MS) constitutes a powerful microanalytical system in the fields of biology, medicine and chemistry. This thesis describes the development of three novel capillary coatings and demonstrates how these extend the utility of CE as a high-efficiency separation technique in protein analysis and biopharmaceutical drug screening. READ MORE

7. 5. Phospholipid membranes in biosensor applications : Stability, activity and kinetics of reconstituted proteins and glycolipids in supported membranes

   Author : Inga Gustafson; Gertrud Puu; Sven Lindskog; Peter Konradsson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Phospholipid films; Liposomes; Membrane proteins; Glycolipids; Ellipsometry; Langmuir Blodgett LB ; Surface plasmon resonance SPR ; Resonant mirror RM ; Atomic force microscopy AFM ; Biosensors; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : In this study the formation of supported membranes onto planar solid supports has been investigated. The stability and activity of reconstituted membrane receptors has been studied. The potential use of such preparations in biosensor applications is discussed.The lipid films were made by the Langmuir Blodgett and by the liposome fusion techniques. READ MORE