Search for dissertations about: "paracellular permeability"

Showing result 1 - 5 of 27 swedish dissertations containing the words paracellular permeability.

  2. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Author : Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. READ MORE

  4. 2. Paracellular permeability of intestinal epithelia.An in vivo study

    Author : Britt-Marie Fihn; Göteborgs universitet; []
    Keywords : paracellular permeability; intestinal epithelia; deoxycholic acid; cholera toxin; glucose absorption; water transport;

    Abstract : Aim: Investigate the importance of paracellular transport of water and solutes during physiological and pathophysiological conditions. Methods: The transport of small water-soluble inert permeability markers, was studied in jejunum and colon in anesthetized rats and cats during normal conditions and during exposure to cholera toxin (CT) and deoxycholic acid (DCA). READ MORE

  5. 3. On the Regulation of the Epithelial Paracellular Permeability

    Author : Pia Nybom; Janove Sehlin; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The epithelia of for instance the small intestine(s) plays a crucial role in the vectorial transport of nutrients and other solutes from the lumen to underlying body fluids, i.e. blood and lymph. READ MORE

  6. 4. Non-digestible Polysaccharides and Intestinal Barrier Function : specific focus on its efficacy in elderly and patients with Crohn’s disease

    Author : John-Peter Ganda Mall; Robert Jan Brummer; Ida Schoultz; Åsa Keita; Mikael Wirén; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-digestible polysachharides; beta-glucan; arabinoxylan; barrier function; permeability; Ussing chamber; elderly; Crohn’s disease;

    Abstract : A large number of elderly suffer from gastrointestinal (GI) symptoms such as constipation and diarrhoea. The underlying mechanisms of age-acquired GI symptoms are not well studied but are necessary to clarify in order to recommend the right treatment. READ MORE

  7. 5. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery

    Author : Eva Krondahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; opioid peptides; permeability; metabolism; oral delivery; pulmonary delivery; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. READ MORE