Search for dissertations about: "Type III secretion system T3SS"

Showing result 1 - 5 of 12 swedish dissertations containing the words Type III secretion system T3SS.

  1. 1. Chemical attenuation of bacterial virulence small molecule inhibitors of type III secretion

    University dissertation from Umeå : Kemi

    Author : Anna Kauppi; Umeå universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. READ MORE

  2. 2. Controlling substrate export by the Ysc-Yop type III secretion system in Yersinia

    University dissertation from Umeå : Umeå universitet

    Author : Ayad Amer; Umeå universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Y. pseudotuberculosis; T3SS; YscX; YopD; assembly; translation control; temporal secretion.; mikrobiologi; Microbiology;

    Abstract : Several pathogenic Gram-negative bacteria invest in sophisticated type III secretion systems (T3SS) to incapacitate their eukaryotic hosts. T3SSs can secrete protein cargo outside the bacterial cell and also target many of them into the eukaryotic cell interior. READ MORE

  3. 3. Small Molecules as Tools in Biological Chemistry Effects of Synthetic and Natural Products on the Type III Secretion System

    University dissertation from Umeå : Umeå universitet

    Author : Caroline E. Zetterström; Umeå universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Abstract : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. READ MORE

  4. 4. Timing and targeting of Type III secretion translocation of virulence effectors in Yersinia

    University dissertation from Umeå : Umeå University

    Author : Sofie Ekestubbe; Umeå universitet.; Umeå universitet.; Umeå universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; virulence; translocation; Yersinia pseudotuberculosis; LcrV; YopN; effector targeting; phagocytosis inhibition; YopH; in vivo infection;

    Abstract : The Type III secretion system (T3SS) is an important virulence mechanism that allows pathogenic bacteria to translocate virulence effectors directly into the cytoplasm of eukaryotic host cells to manipulate the host cells in favor of the pathogen. Enteropathogenic Yersinia pseudotuberculosis use a T3SS to translocate effectors, Yops, that prevent phagocytosis by immune cells, and is largely dependent on it to establish and sustain an infection in the lymphoid tissues of a mammalian host. READ MORE

  5. 5. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

    University dissertation from Umeå : Molekylärbiologi (Teknat- och Medfak)

    Author : Petra J Edqvist; Umeå universitet.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; NATURAL SCIENCES Chemistry Biochemistry Molecular biology; NATURVETENSKAP Kemi Biokemi Molekylärbiologi;

    Abstract : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. READ MORE