Search for dissertations about: "gene target prediction"

Showing result 21 - 25 of 32 swedish dissertations containing the words gene target prediction.

  2. 21. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics

    Author : Emmy Borgmästars; Malin Sund; Ola Billing; Pär Jonsson; Zelmina Lubovac-Pilav; Oskar Franklin; Stefan Enroth; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pancreatic cancer; microRNA functional analysis; TPS; miRNomics; metabolomics; proteomics; plasma samples; early detection; risk; survival;

    Abstract : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. READ MORE

  4. 22. The study of sensory cilia development in caenorhabditis elegans

    Author : Evgeni Efimenko; Peter Swoboda; Philippe Bastin; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Cilia and flagella are widespread eukaryotic subcellular components that are conserved from green algae to mammals. In different organisms they function in cell motility, movement of extracellular fluids and sensory reception. READ MORE

  5. 23. Uncovering the genetics underlying host-parasite interactions during Plasmodium falciparum malaria transmission

    Author : Mubasher Mohammed; Johan Ankarklev; David Serre; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; Plasmodium falciparum; Genomics; single-cell RNA-seq; Parasite cell fate; Anopheles gambiae; ApiAP2 transcription factors; driver genes; computational biology; molekylär biovetenskap; Molecular Bioscience;

    Abstract : In eukaryotes, cellular differentiation is often orchestrated by programmed arrays of activation and repression of genes underlying the specific phenotypes of cell-types. To complete its life cycle, the single-celled Apicomplexan parasite Plasmodium falciparum, the most deadly of the human malaria parasites, must repeatedly differentiate and convert into unique cell types that can exploit niches within their human and mosquito hosts. READ MORE

  6. 24. Cell-penetrating peptides targeting glioblastomas for nucleic acid delivery in the blood-brain barrier model

    Author : Artita Srimanee; Ülo Langel; Ines Neundorf; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Blood-brain barrier model; nucleic acid delivery; glioblastomas; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Glioblastoma multiforme is the most aggressive form of malignant brain tumor with poor prognosis. The efficacy of brain cancer treatment by chemotherapeutics is limited by the blood-brain barrier (BBB) which allows less than 2% of the small molecules and blocks almost all the macromolecules to transport into the brain. READ MORE

  7. 25. Remodelling of the cellular environment in Epstein-Barr virus infection

    Author : Simone Callegari; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : For successful infection viruses modify the host cell environment by transcriptional, posttranscriptional or post-translational regulation of cellular signaling pathways. In the work described in this thesis bioinformatics analysis coupled with biochemical validations were used to dissect critical features of these viral strategies in the context of infection by Epstein–Barr virus (EBV), a human herpesvirus associated with lymphoid and epithelial cell tumors. READ MORE