An approach to the synthesis of O-glycopeptides

Abstract: Synthesis of glycopeptides using a solid phase technique has been performed. The preparation of suitably protected glycosylated amino acids and the successful use of these derivatives in solid phase synthesis of two glycopeptides are described. The target molecules were the minimal epitope of the monoclonal antibody FDC6 towards oncofetal human Fibronectin, and a glycosylated cyclic peptide related to the first loop of the EGFlike domain of bovine factor IX.