Search for dissertations about: "selectivity"

Showing result 1 - 5 of 543 swedish dissertations containing the word selectivity.

  1. 1. Selectivity in NMR and LC-MS Metabolomics The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Albert Elmsjö; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; NMR; LC-MS; HILIC; UHPLC; Q-ToF; selectivity; co-feature ratio; method evaluation; data evaluation; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. READ MORE

  2. 2. Serine Hydrolase Selectivity Kinetics and applications in organic and analytical chemistry

    University dissertation from Stockholm : KTH

    Author : Anders Hamberg; KTH.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica lipase B; monoacylation of diols; kinetic resolution; thermodynamics in enzyme catalysis; enzyme engineering; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. READ MORE

  3. 3. Muscarinic receptors and urinary bladder selectivity : Properties that determine the organ selectivity of compounds

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Staffan Sundquist; Uppsala universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; bladder; muscarinic; receptor subtypes; smooth muscle; multivariate; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutics; galenisk farmaci;

    Abstract : Urinary bladder contraction is mainly mediated by activation of muscarinic acetylcholine receptors (mAChR). Muscarinic antagonists are often effective in treatment of unstable bladder. The effectiveness of this treatment has often been limited by side effects as dry mouth. READ MORE

  4. 4. EC State aid rules An analysis of the selectivity criterion

    University dissertation from Uppsala : Juridiska institutionen

    Author : Mona Aldestam; Uppsala universitet.; [2005]
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; European law; EC State aid; Taxation; Derogation; Benchmark; Norm; Selectivity criterion; Justifications; Europarätt; LAW JURISPRUDENCE Other law European law; RÄTTSVETENSKAP JURIDIK Övrig rätt EU-rätt; Jurisprudence; Allmän rättslära;

    Abstract : The application of Art. 87(1) EC to taxes above all is connected to the application of the derogation method, which appears to be part of the selectivity criterion. This dissertation examines the application of the derogation method and the assessment of the selectivity criterion applied to taxes, primarily de lege lata, but also de lege ferenda. READ MORE

  5. 5. Exploring Selectivity and Hysteresis Kinetic Studies on a Potato Epoxide Hydrolase

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Diana Lindberg; Uppsala universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Epoxide hydrolase; regioselectivity; selectivity; hysteresis; conformational changes; cooperativity; deep eutectic solvents; methylstyrene oxide; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; Biokemi; Biochemistry;

    Abstract : The kinetic mechanism of an α/β hydrolase fold epoxide hydrolase from potato, StEH1, has been studied with the aims of explaining the underlying causes for enantio- and regioselectivity, both being important for product purity. Further effort has been laid upon understanding the causes of a hysteretic behavior discovered in the measurements leading to Paper I. READ MORE