Search for dissertations about: "15-PGDH"

Found 5 swedish dissertations containing the word 15-PGDH.

  2. 1. Role of novel tumor suppressors in colon cancer : Mechanisms and therapeutic opportunities

    Author : LUBNA MEHDAWI; Malmö Cellpatologi; []
    Keywords : Tumor Suppressor Genes; 15-PGDH; WNT5A;

    Abstract : Colon cancer is the third most common cancer in the world and the fourth most common cause of cancer related deaths. Inflammation is one of the risk factors for development of colon cancer. Interestingly immune cells as mast cells and inflammatory mediators as LTC4 play an important role in colon cancer. READ MORE

  4. 2. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Author : Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). READ MORE

  5. 3. Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment

    Author : Karina Roxana Gheorghe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss of function. This condition affects 0. READ MORE

  6. 4. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

    Author : Syrina Mehrabi; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

    Abstract : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. READ MORE

  7. 5. Novel therapy for neuroblastoma : focus on prostaglandin E2 and microsomal prostaglandin E synthases-1

    Author : Anna Kock; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is a major public health problem and to date cancer is one of the leading causes of death worldwide. Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system. Neuroblastoma is one of the most common and deadliest extra cranial tumors of childhood. READ MORE