Search for dissertations about: "Burkitt s lymphoma"
Showing result 1 - 5 of 13 swedish dissertations containing the words Burkitt s lymphoma.
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1. Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma
Abstract : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. READ MORE
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2. Impact of malaria on B-cell homeostasis and Epstein-Barr virus reactivation : endemic Burkitt's lymphoma pathogenesis
Abstract : Over recent years, the concept that many diseases can be aetiologically linked to infection by more than one pathogen has gained increased attention and awareness. Plasmodium falciparum (P. READ MORE
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3. In silico analysis of pathways targeted by EBV infection and malignant transformation
Abstract : Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus with dual cell tropism for human B-lymphocytes and epithelial cells. EBV infection is linked to several malignancies such as Burkitt s lymphoma (BL) and nasopharyngeal carcinoma (NPC). READ MORE
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4. Functional characterization of the alternative reading frame protein p14ARF
Abstract : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. READ MORE
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5. The role of the microenvironment on the regulation of Epstein-Barr virus latent gene expression
Abstract : Epstein-Barr virus (EBV) is a human-specific gamma-herpes virus of the Lymphocryptovirus genus that has succeeded to colonize more than 90% of the adult population. EBV s coevolution with humans has established a largely harmless co-existence that depends on the variability of viral gene expression and on the immunological host response. READ MORE