Search for dissertations about: "Clostridium botulinum"

Found 5 swedish dissertations containing the words Clostridium botulinum.

  1. 1. Botulinum neurotoxins

    Author : Sara Persson Košenina; Pål Stenmark; Rongsheng Jin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxins; biokemi; Biochemistry;

    Abstract : Botulinum neurotoxins (BoNTs) are the most potent toxins known to man, with less than 1 μg of pure toxin being enough to kill an adult man. Despite the high toxicity, BoNTs are widely used in cosmetics and in medicine for the treatment of an increasing number of medical conditions. READ MORE

  2. 2. Real-time PCR for diagnosis of botulism and quantification of neurotoxin gene expression in Clostridium botulinum

    Author : Ingrid Artin; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; detection; qRT-PCR; Clostridium botulinum; molecular methods;

    Abstract : The objectives of the work presented in this thesis have been to develop molecular methods for (i) detection of Clostridium botulinum in food and clinical samples, and (ii) monitoring the expression of the neurotoxin gene, cnt, during different growth phases and under different growth conditions. For the diagnosis of botulism, a real-time PCR-based method including an internal amplification control for C. READ MORE

  3. 3. A Molecular Approach for Investigation of the Prevalence and Neurotoxin Formation of Clostridium botulinum in Food Safety Assessment

    Author : Maria Lövenklev; Teknisk mikrobiologi; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; neurotoxin gene expression; neurotoxin; food safety assessment; food preservation; Clostridium botulinum; enrichment PCR; Food and drink technology; qRT-PCR; Livsmedelsteknik; prevalence;

    Abstract : In the development of new food products, more knowledge is needed about the occurrence and quantity of food-borne pathogens in the food chain to be able to implement effective control measures and assure food safety. In addition, improved understanding of how environmental factors and food preservatives effect the microbial virulence expression in foods will enable the formulation of new strategies for food preservation and risk assessment. READ MORE

  4. 4. Structural Insights into Botulinum Neurotoxins and the ALFA-tag System : Structural and Functional Studies of Proteins Related to the Botulinum Neurotoxins and Design of a Novel Epitope Tag

    Author : Markel Martínez-Carranza; Pål Stenmark; Thomas Binz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxin; Biochemistry; biokemi;

    Abstract : This thesis is divided into two sections; the first part describes our work in the field of botulinum neurotoxins (presented in papers I, II, III, and manuscript IV) and the second part summarizes our work involving the design of a new biochemical tool (presented in paper V).Botulinum neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinum are the most poisonous substances known to date. READ MORE

  5. 5. Genomic organization and diversity of Clostridium botulinum group III : the bug behind animal botulism

    Author : Hanna Skarin; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []

    Abstract : Botulism is caused by botulinum neurotoxins (BoNTs) produced by the spore forming strictly anaerobic bacterium Clostridium botulinum. Seven different types of BoNTs (type A-F) have so far been established on the basis of neutralization with different antibodies. READ MORE