Search for dissertations about: "omics"

Showing result 1 - 5 of 97 swedish dissertations containing the word omics.

  1. 1. Interpretation of variation in omics data : Applications in proteomics for sustainable agriculture

    Author : Jakob Willforss; Institutionen för immunteknologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; agriculture; proteomics; omics; biomarker; normalization; batch effect; visualization; software;

    Abstract : Biomarkers are used in molecular biology to predict characteristics of interest and are applied in agriculture to accelerate the breeding of target traits. Proteomics has emerged as a promising technology for improved markers by providing a closer view to the phenotype than conventional genome-based approaches. READ MORE

  2. 2. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

    Author : Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

    Abstract : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. READ MORE

  3. 3. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine

    Author : Klev Diamanti; Jan Komorowski; Claes Wadelius; Manfred Grabherr; Peter Spégel; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; multi-omics; genomics; metabolomics; data science; machine learning; personalized medicine; Bioinformatics; Bioinformatik;

    Abstract : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. READ MORE

  4. 4. Omics Data Analysis of Complex Diseases and Traits

    Author : Saman Hosseini Ashtiani; Arne Elofsson; Dirk Repsilber; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; Omics data; RNA-seq; Microarrays; Metabolomics; Network analysis; Psoriasis; E. coli; Hip osteoporosis; Lung adenocarcinoma; Spearman s correlation coefficient; LC-MS; PCA; DEG; PPI; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Following the advent of the high-throughput techniques for producing massive omics data, new possibilities and challenges have also emerged in different fields of biology and medicine. Dealing with such data on different scales with different scopes such as genomics, transcriptomics, proteomics and metabolomics, demands appropriate data collection, preprocessing, statistical analysis, interpretation and visualization. READ MORE

  5. 5. Statistically Guided Visualization and Exploratory Analysis of Omics Data

    Author : Charlotte Soneson; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioinformatics; Exploratory analysis; Multidimensional Scaling; Omics data; Principal component analysis; Visualization;

    Abstract : This thesis deals with methods for extracting robust and relevant information from high-dimensional data sets, and statistically guided visualization methods for representing the data in an informative and easily accessible way. High-dimensional data sets are becoming increasingly prevalent in many different scientific disciplines. READ MORE