Search for dissertations about: "Liposomes"

Showing result 1 - 5 of 95 swedish dissertations containing the word Liposomes.

  1. 1. Liposomes for Drug Delivery from Physico-chemical Studies to Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nill Bergstrand; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; liposome; steric stabilisation; BNCT; cryo-TEM; EGF; targeting; stability; permeability; pH-sensitive liposomes; triggered release; Fysikalisk kemi; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : Physico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. READ MORE

  2. 2. Two-Step Targeting for Effective Radionuclide Therapy Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Amelie Fondell; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. READ MORE

  3. 3. Equilibrium and Kinetic Studies of the Binding of DNA to Cationic Liposomes

    University dissertation from Physical Chemistry 1, Lund University

    Author : Paula Barreleiro; Lund University.; Lunds universitet.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Small-Angle Neutron Scattering; Fluorescence; Kinetics; Stopped-Flow; Differential Scanning Calorimetry; Titration Calorimetry; Gel-to-Liquid Crystalline Phase Transition; Lamellar phase; Lipolexes; DNA; Liposomes; Cryo-TEM; Physical chemistry; Fysikalisk kemi;

    Abstract : The objective of this work was to study the formation of DNA-cationic vesicle complexes (lipoplexes). These complexes are interesting not only from a fundamental point of view but also as promising candidates for gene therapy. The approach taken was to study first the cationic vesicles by themselves. READ MORE

  4. 4. Structure and stability of liposomes : Interactions with micelle- forming surfactants

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mats Silvander; Uppsala universitet.; [1999]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; Fysik; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik; Physical Chemistry; fysikalisk kemi;

    Abstract : The stability of phospholipid lipomes interacting with micelle-forming surfactants was studied under physiological conditions (150 mM NaCl and pH=7.4 unless otherwise stated) mainly by use of cryo-TEM and fluorescence. READ MORE

  5. 5. Quantitative Aspects of Nanodelivery Across the Blood-Brain Barrier Exemplified with the Opioid Peptide DAMGO

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Annika Lindqvist; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood-brain barrier; liposomes; nanocarriers; brain delivery; pharmacokinetics; modeling and simulation; microdialysis; opioid peptide; DAMGO; LC-MS MS; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. READ MORE